Arjmandi B H, Craig J, Nathani S, Reeves R D
Department of Foods and Nutrition, Kansas State University, Manhattan 66506.
J Nutr. 1992 Jul;122(7):1559-65. doi: 10.1093/jn/122.7.1559.
Ninety-six male Sprague-Dawley rats were randomly assigned to eight dietary treatments. Rats were fed, with ad libitum access, diets containing 10% dietary fiber as cellulose (control), pectin, psyllium or oat bran with or without 0.3% added cholesterol for 3 wk. Among cholesterol-fed rats, liver total cholesterol was significantly lower in rats fed diets supplemented with either pectin or psyllium compared with those fed cellulose. In contrast, rats fed oat bran with cholesterol had significantly higher liver cholesterol concentrations compared with cellulose-fed animals. Liver total lipid concentrations were significantly lower in groups fed pectin and psyllium with or without dietary cholesterol compared with cellulose-fed controls. Pectin feeding with or without dietary cholesterol significantly lowered plasma total cholesterol compared with cellulose feeding. Oat bran had no effect on plasma total cholesterol compared with control diets. Hepatic sterol synthesis was significantly greater for animals fed soluble dietary fibers compared with those fed cellulose, but the effect on intestinal sterol synthesis was less pronounced.
96只雄性斯普拉格-道利大鼠被随机分配到8种饮食处理组。大鼠自由采食含10%膳食纤维（分别为纤维素（对照组）、果胶、车前子壳或燕麦麸）且添加或不添加0.3%胆固醇的饲料，持续3周。在喂食胆固醇的大鼠中，与喂食纤维素的大鼠相比，喂食添加果胶或车前子壳饲料的大鼠肝脏总胆固醇显著降低。相反，与喂食纤维素的动物相比，喂食含胆固醇燕麦麸的大鼠肝脏胆固醇浓度显著更高。与喂食纤维素的对照组相比，喂食含或不含膳食胆固醇的果胶和车前子壳的组肝脏总脂质浓度显著更低。与喂食纤维素相比，喂食含或不含膳食胆固醇的果胶可显著降低血浆总胆固醇。与对照饮食相比，燕麦麸对血浆总胆固醇没有影响。与喂食纤维素的动物相比，喂食可溶性膳食纤维的动物肝脏固醇合成显著增加，但对肠道固醇合成的影响不太明显。
