Hawks D, Peterson M E, Hawkins K L, Rosebury W S
Veterinary Hospital, University of Pennsylvania, Philadelphia.
J Vet Intern Med. 1992 May-Jun;6(3):193-6. doi: 10.1111/j.1939-1676.1992.tb00336.x.
A functional, insulin-secreting pancreatic (islet cell) carcinoma was diagnosed in a 17-year-old male Siamese cat. Diagnosis was made on the basis of clinical signs (i.e., seizures and stupor) that resolved temporarily after correction of hypoglycemia with feeding or intravenous administration of glucose, the finding of an inappropriately increased serum insulin concentration in the face of hypoglycemia, and prolonged resolution of hypoglycemia after surgical removal of the tumor. Primary islet cell tumor of the pancreas was confirmed by biopsy. The cat died 18 months later, and necropsy revealed metastases to regional lymph nodes and liver. Specimens of the tumor and metastatic lesions both stained positively for insulin.
一只17岁的雄性暹罗猫被诊断出患有功能性胰岛素分泌性胰腺（胰岛细胞）癌。诊断依据为临床症状（即癫痫发作和昏迷），在通过喂食或静脉注射葡萄糖纠正低血糖后症状暂时缓解，在低血糖情况下发现血清胰岛素浓度异常升高，以及手术切除肿瘤后低血糖持续缓解。胰腺原发性胰岛细胞瘤经活检确诊。这只猫18个月后死亡，尸检发现有区域淋巴结和肝脏转移。肿瘤和转移病灶的标本胰岛素染色均呈阳性。
