COUPERUS M
Calif Med. 1954 Dec;81(6):402-6.
Eighteen patients with vitiligo were treated with two crystalline substances, xanthotoxin (Ammoidin) and imperatorin (Ammidin) from the plant Ammi majus. Four patients improved more than 50 per cent. One had complete cure, but depigmentation recurred after a few months. Six patients had moderate improvement (less than 50 per cent), three had slight repigmentation, and in five cases there was no improvement. These results are similar to those reported by other investigators.Pronounced local inflammatory reactions are to be expected after exposure to ultraviolet light in nearly all patients treated with xanthotoxin. In one case prolonged sensitivity to sunlight, manifest by vesiculating dermatitis, occurred.
18名白癜风患者接受了两种晶体物质治疗，这两种物质分别是从植物大阿米芹中提取的补骨脂素（白芷素）和异补骨脂素（异白芷素）。4名患者改善超过50%。1名患者完全治愈，但几个月后色素脱失复发。6名患者有中度改善（小于50%），3名患者有轻微色素再沉着，5名患者无改善。这些结果与其他研究者报告的结果相似。几乎所有接受补骨脂素治疗的患者在暴露于紫外线后都会出现明显的局部炎症反应。有1例出现了对阳光的长期敏感，表现为水疱性皮炎。
