Kharkevich D A, Aliautdin R N, Kasparov S A, Nemirovskiĭ A Iu, Tankovich N I
Farmakol Toksikol. 1985 Sep-Oct;48(5):32-5.
Magnetically carried microspheres were used to investigate whether the curare-like drugs can be selectively transported to the muscles of one of the limbs of the cat. Pyrocurine and diadonium incorporated in such microspheres primarily suppressed neuromuscular transmission in the limb placed in magnetic field as compared with the control placed outside the field. The use of magnetic microspheres cointaining pyrocurine and diadonium produced no changes in systemic arterial blood pressure, local blood flow, EEG or ECG. The method also diminished the respiratory depression produced by the curare-like substances when they are routinely used for body muscle relaxation.
磁性携带微球被用于研究箭毒样药物是否能够选择性地转运至猫某一肢体的肌肉。与置于磁场外的对照组相比，掺入此类微球中的焦箭毒碱和二铵主要抑制置于磁场中的肢体的神经肌肉传递。使用含有焦箭毒碱和二铵的磁性微球不会引起全身动脉血压、局部血流、脑电图或心电图的变化。当箭毒样物质常规用于全身肌肉松弛时，该方法还减轻了它们所产生的呼吸抑制作用。
