Drozhzhin A P, Ibadova D N
Farmakol Toksikol. 1976 Jan-Feb;39(1):21-5.
Lengthening of the N-alkyl radical (from--C2H5 to C10H21) in the series of polymethylene-bis-quaternary ammonium compounds was found to result in an increased hydrophobic properties of the compounds. In the presence of the N-butyl radical the mode of the action exerted by the substances changes, viz. from depolarizing they turn into antidepolarizing ones. A substitution of polyalicyclic radicals (cyclohexyl, 1-adamantyl) for methyl groups at the nitrogen atoms in the series of polymethylene-bis-quaternary ammonium compounds proved that in order to changed the mode of action hydrophobic properties of the cyclohexyl radicals appear to be good enough.
在聚亚甲基双季铵化合物系列中，发现N - 烷基（从 - C₂H₅到C₁₀H₂₁）的延长会导致化合物疏水性增加。在存在N - 丁基时，这些物质发挥作用的方式会发生变化，即从去极化作用转变为抗去极化作用。在聚亚甲基双季铵化合物系列中，用多脂环族基团（环己基、1 - 金刚烷基）取代氮原子上的甲基，结果证明，为了改变作用方式，环己基的疏水性质似乎就足够了。
