吗啡诱导运动的苍白球基质

Pallidal substrate of morphine-induced locomotion.

作者信息

Anagnostakis Y, Krikos Y, Spyraki C

机构信息

Department of Basic Sciences, Medical School, University of Crete, Heraklion, Greece.

出版信息

Eur Neuropsychopharmacol. 1992 Mar;2(1):65-72. doi: 10.1016/0924-977x(92)90038-a.

DOI:10.1016/0924-977x(92)90038-a

PMID:1322211

Abstract

Bilateral microinjections of morphine hydrochloride (5.0; 7.5; 10.0 micrograms/0.5 microliters/side) or saline were infused into 3 different regions (dorsal, medial, ventral) of the rat globus pallidus, to examine their effects on locomotor activity. Locomotor activity of each rat was measured 45 min before and 90 min after saline or morphine pallidal microinjections. Morphine induced a dose-dependent increase in locomotion. This increase in locomotion was also significantly different between the 3 pallidal regions. Pretreatment with naloxone (1 mg/kg, sc) inhibited the morphine (7.5 micrograms) hyperlocomotion elicited from all three pallidal areas. The results suggest that the entire pallidum serves as substrate of morphine hyperlocomotion mediated by opiate receptors.

摘要

将盐酸吗啡（5.0；7.5；10.0微克/0.5微升/侧）或生理盐水双侧微量注射到大鼠苍白球的3个不同区域（背侧、内侧、腹侧），以研究它们对运动活动的影响。在生理盐水或吗啡苍白球微量注射前45分钟和注射后90分钟测量每只大鼠的运动活动。吗啡引起运动的剂量依赖性增加。这种运动增加在3个苍白球区域之间也有显著差异。用纳洛酮（1毫克/千克，皮下注射）预处理可抑制从所有三个苍白球区域引发的吗啡（7.5微克）所致的运动亢进。结果表明，整个苍白球是阿片受体介导的吗啡运动亢进的底物。