吗啡和纳洛酮对大鼠强直性静止和背部静止反应的影响。
Morphine and naloxone effects on tonic immobility and the dorsal immobility response in the rat.
作者信息
Smith R L, Meyer M E
出版信息
Pharmacol Biochem Behav. 1985 Apr;22(4):505-7. doi: 10.1016/0091-3057(85)90265-5.
Adult male Wistar rats treated with morphine sulfate (0.5, 5.0, and 10.0 mg/kg, SC) showed a dose-dependent potentiation of tonic immobility (TI) and dorsal immobility response (DIR) durations. Naloxone (4.0 mg/kg, SC) did not affect the DIR durations but reversed the potentiated morphine effects on both TI and DIR. These results suggest that although opiate receptors may be involved, mu-opiate receptor function is not essential for modulating various complex immobility responses.
用硫酸吗啡（0.5、5.0和10.0毫克/千克，皮下注射）处理的成年雄性Wistar大鼠表现出强直性不动（TI）和背部不动反应（DIR）持续时间的剂量依赖性增强。纳洛酮（4.0毫克/千克，皮下注射）不影响DIR持续时间，但可逆转吗啡对TI和DIR的增强作用。这些结果表明，虽然阿片受体可能参与其中，但μ-阿片受体功能对于调节各种复杂的不动反应并非必不可少。
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