溶血巴斯德菌白细胞毒素可增强牛多形核白细胞白三烯B4和5-羟基二十碳四烯酸的生成。
Pasteurella haemolytica leukotoxin enhances production of leukotriene B4 and 5-hydroxyeicosatetraenoic acid by bovine polymorphonuclear leukocytes.
作者信息
Henricks P A, Binkhorst G J, Drijver A A, Nijkamp F P
机构信息
Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, The Netherlands.
出版信息
Infect Immun. 1992 Aug;60(8):3238-43. doi: 10.1128/iai.60.8.3238-3243.1992.
Abstract
The influence of the leukotoxin of Pasteurella haemolytica on the generation of arachidonic acid metabolites by bovine polymorphonuclear leukocytes (PMNs) was investigated. PMNs released 5-, 12-, and 15-hydroxyeicosatetraenoic acids (5-, 12-, and 15-HETE) and leukotriene B4 (LTB4) upon stimulation with arachidonic acid. The leukotoxin preparations dose dependently enhanced the release of the 5-lipoxygenase products 5-HETE and LTB4 in arachidonic acid-stimulated PMNs, whereas the release of 12- and 15-HETE was not affected. The enhanced release of LTB4 and 5-HETE was not due to a decreased cellular retention of the 5-lipoxygenase products. In addition, leukotoxin preparations by themselves were also able to induce LTB4 and 5-HETE production in the absence of exogenous arachidonic acid. Generation of 5-lipoxygenase products by PMNs stimulated by leukotoxin may represent an important cellular event that occurs during infections with P. haemolytica.
摘要
研究了溶血巴斯德菌白细胞毒素对牛多形核白细胞（PMN）花生四烯酸代谢产物生成的影响。PMN在受到花生四烯酸刺激后会释放5-、12-和15-羟基二十碳四烯酸（5-、12-和15-HETE）以及白三烯B4（LTB4）。白细胞毒素制剂在花生四烯酸刺激的PMN中剂量依赖性地增强了5-脂氧合酶产物5-HETE和LTB4的释放，而12-和15-HETE的释放未受影响。LTB4和5-HETE释放的增强并非由于5-脂氧合酶产物细胞内保留的减少。此外，白细胞毒素制剂自身在没有外源性花生四烯酸的情况下也能够诱导LTB4和5-HETE的产生。由白细胞毒素刺激的PMN产生5-脂氧合酶产物可能代表了溶血巴斯德菌感染期间发生的一个重要细胞事件。
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本文引用的文献
1
Evidence of species specificity in the cytocidal effects of Pasteurella haemolytica.溶血巴斯德氏菌细胞杀伤作用中物种特异性的证据。
Infect Immun. 1980 Nov;30(2):615-6. doi: 10.1128/iai.30.2.615-616.1980.
2
Kinetics of interaction and fate of Pasteurella hemolytica in bovine alveolar macrophages.溶血巴斯德氏菌在牛肺泡巨噬细胞中的相互作用动力学及归宿
Infect Immun. 1980 Oct;30(1):254-62. doi: 10.1128/iai.30.1.254-262.1980.
3
Cytotoxic effects of Pasteurella haemolytica on bovine neutrophils.溶血巴斯德菌对牛中性粒细胞的细胞毒性作用。
Am J Vet Res. 1981 Aug;42(8):1383-8.
4
Cytotoxin of Pasteurella haemolytica acting on bovine leukocytes.溶血巴斯德氏菌作用于牛白细胞的细胞毒素。
Infect Immun. 1982 Jan;35(1):91-4. doi: 10.1128/iai.35.1.91-94.1982.
5
6
A review of the lesions in shipping fever of cattle.牛运输热病变综述。
Can Vet J. 1981 Jan;22(1):1-8.
7
Arachidonic acid 15-lipoxygenase products from human eosinophils.来自人类嗜酸性粒细胞的花生四烯酸15-脂氧合酶产物。
J Biol Chem. 1982 Jun 25;257(12):7068-76.
8
Effect of Escherichia coli alpha-hemolysin on human peripheral leukocyte function in vitro.大肠杆菌α-溶血素对人外周血白细胞体外功能的影响。
Infect Immun. 1982 Sep;37(3):966-74. doi: 10.1128/iai.37.3.966-974.1982.
9
Lipoxygenase activity of intact human platelets.完整人血小板的脂氧合酶活性
Prostaglandins Leukot Med. 1984 Jan;13(1):61-6. doi: 10.1016/0262-1746(84)90103-3.
10
In vitro cytotoxic effect of alpha-hemolytic Escherichia coli on human blood granulocytes.α-溶血大肠杆菌对人血粒细胞的体外细胞毒性作用。
Infect Immun. 1984 Jul;45(1):255-60. doi: 10.1128/iai.45.1.255-260.1984.
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