Iscovich J M, L'Abbé K A, Castelleto R, Calzona A, Bernedo A, Chopita N A, Jmelnitzsky A C, Kaldor J, Howe G R
Department of Epidemiology Studies, Ministry of Health, La Plata, Argentina.
Int J Cancer. 1992 Jul 30;51(6):858-61. doi: 10.1002/ijc.2910510604.
A case-control study has been conducted to investigate the relationship between total energy intake, fibre and nutrients and colon cancer in Argentina. Cases are 110 newly diagnosed patients from 10 hospitals between 1985 and 1986. Two neighbourhood controls per case were matched on age, sex and place of residence. The intake of calories, fibre and nutrients was estimated from the information collected on food consumption during the 5-year period up to 6 months prior to interview of subjects, based on a pilot study and standard portion sizes in Argentina. In conditional regression models, dietary fibre is highly protective (odds ratio (OR) = 0.07 per 19.02 g/day; 95% confidence interval (CI): 0.02 to 0.25) and total energy intake increases risk (RR = 1.82 per 1000 kcal/day; 95% CI: 1.20 to 2.77), each with adjustment for the other. Analysis of caloric components (fat, protein and carbohydrates) reveals that carbohydrates are the most important factor driving the total energy effect. Other nutrients make little apparent contribution to risk.
在阿根廷开展了一项病例对照研究，以调查总能量摄入、纤维和营养素与结肠癌之间的关系。病例为1985年至1986年期间来自10家医院的110例新诊断患者。每个病例匹配两名邻居对照，对照在年龄、性别和居住地点方面与病例相匹配。根据阿根廷的一项初步研究和标准份量，依据在对受试者进行访谈前6个月内直至5年期间收集的食物消费信息，估算卡路里、纤维和营养素的摄入量。在条件回归模型中，膳食纤维具有高度保护作用（比值比（OR）=每19.02克/天为0.07；95%置信区间（CI）：0.02至0.25），总能量摄入会增加风险（相对危险度（RR）=每1000千卡/天为1.82；95%CI：1.20至2.77），两者在相互调整后得出上述结果。对热量成分（脂肪、蛋白质和碳水化合物）的分析表明，碳水化合物是导致总能量效应的最重要因素。其他营养素对风险的影响不明显。
