Ber-H2（抗CD30）-皂草毒素免疫毒素：治疗霍奇金病和CD30+淋巴瘤的新工具：体外评估
Ber-H2 (anti-CD30)-saporin immunotoxin: a new tool for the treatment of Hodgkin's disease and CD30+ lymphoma: in vitro evaluation.
作者信息
Tazzari P L, Bolognesi A, de Totero D, Falini B, Lemoli R M, Soria M R, Pileri S, Gobbi M, Stein H, Flenghi L
机构信息
Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.
出版信息
Br J Haematol. 1992 Jun;81(2):203-11. doi: 10.1111/j.1365-2141.1992.tb08208.x.
An immunotoxin containing an anti-CD30 monoclonal antibody (Ber-H2) and saporin, a ribosome-inactivating protein type 1, is described. It specifically inhibits protein synthesis by Hodgkin derived target cell lines with a very high efficiency (IC50 ranging from 5 x 10(-12) M to 5 x 10(-14) M, as saporin), while irrelevant immunotoxins do not. Present results suggest that this immunotoxin could be used for in vivo therapy as well as for ex vivo bone marrow purging in Hodgkin's disease and CD30+ lymphomas.
描述了一种免疫毒素，其包含抗CD30单克隆抗体（Ber-H2）和I型核糖体失活蛋白皂草素。它能高效特异性抑制霍奇金来源的靶细胞系的蛋白质合成（以皂草素计，IC50范围为5×10^(-12) M至5×10^(-14) M），而无关的免疫毒素则无此作用。目前的结果表明，这种免疫毒素可用于霍奇金病和CD30+淋巴瘤的体内治疗以及体外骨髓净化。
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