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亨廷顿舞蹈病患者血浆生长激素浓度

Plasma growth hormone concentrations in Huntington's chorea.

作者信息

Phillipson O T, Bird E D

出版信息

Clin Sci Mol Med. 1976 Jun;50(6):551-4. doi: 10.1042/cs0500551.

DOI:10.1042/cs0500551
PMID:132332
Abstract
  1. Growth hormone secretion was assessed in nine control subjects and nine patients with Huntington's chorea. 2. Early-morning fasting plasma samples from patients with Huntington's chorea contained abnormally high concentrations of growth hormone. 3. The suppression of growth hormone after oral glucose in choreic patients, unlike the control subjects, occurred at irregular intervals after the glucose was given and was followed, again at irregular intervals, by an exaggerated rebound phase. 4. The response to intravenous insulin was not markedly abnormal in choreic patients. However, there was a significant increase in the rate of rise of growth hormone concentration in the first half and hour after the insulin injection when compared with control subjects.
摘要
  1. 对9名对照受试者和9名患有亨廷顿舞蹈症的患者的生长激素分泌情况进行了评估。2. 亨廷顿舞蹈症患者清晨空腹血浆样本中生长激素浓度异常高。3. 与对照受试者不同,舞蹈症患者口服葡萄糖后生长激素的抑制情况在给予葡萄糖后间隔不规律,随后又间隔不规律地出现夸张的反弹期。4. 舞蹈症患者对静脉注射胰岛素的反应没有明显异常。然而,与对照受试者相比,胰岛素注射后前半小时生长激素浓度上升速率显著增加。

相似文献

1
Plasma growth hormone concentrations in Huntington's chorea.亨廷顿舞蹈病患者血浆生长激素浓度
Clin Sci Mol Med. 1976 Jun;50(6):551-4. doi: 10.1042/cs0500551.
2
Plasma glucose, non-esterified fatty acids and amino acids in Huntington's chorea.亨廷顿舞蹈病中的血浆葡萄糖、非酯化脂肪酸和氨基酸
Clin Sci Mol Med. 1977 Mar;52(3):311-8. doi: 10.1042/cs0520311.
3
Exaggerated growth hormone response to arginine infusion in Huntington's disease.亨廷顿舞蹈症患者对精氨酸输注的生长激素反应过度。
J Clin Endocrinol Metab. 1975 Jul;41(1):160-3. doi: 10.1210/jcem-41-1-160.
4
[Fatty acid patterns and glucose tolerance in Huntington's chorea (author's transl)].亨廷顿舞蹈病中的脂肪酸模式与葡萄糖耐量(作者译)
Res Exp Med (Berl). 1976 Jul 2;167(3):203-15. doi: 10.1007/BF01851645.
5
Abnormal glucose tolerance and arginine tolerance tests in Huntington's disease.亨廷顿舞蹈病患者的葡萄糖耐量试验及精氨酸耐量试验异常。
Gerontology. 1977;23(1):55-63. doi: 10.1159/000212174.
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Altered growth hormone and prolactin responses to dopaminergic stimulation in Huntington's chorea.亨廷顿舞蹈病中生长激素和催乳素对多巴胺能刺激的反应改变。
J Clin Endocrinol Metab. 1977 May;44(5):870-5. doi: 10.1210/jcem-44-5-870.
7
Twenty-four hour plasma levels of growth hormone and prolactin in Huntington's disease.亨廷顿舞蹈病患者生长激素和催乳素的24小时血浆水平
J Neurol Neurosurg Psychiatry. 1983 Dec;46(12):1134-7. doi: 10.1136/jnnp.46.12.1134.
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Altered growth hormone release in Huntington's chorea.亨廷顿舞蹈病中生长激素释放的改变。
J Neurol Neurosurg Psychiatry. 1976 Mar;39(3):244-8. doi: 10.1136/jnnp.39.3.244.
9
[Huntington's chorea and somatotropic hormone: dynamic explorations in 27 cases (author's transl)].
Rev Neurol (Paris). 1981;137(1):21-31.
10
Spontaneous nocturnal plasma prolactin and growth hormone secretion in patients with Parkinson's disease and Huntington's chorea.帕金森病和亨廷顿舞蹈病患者夜间血浆催乳素和生长激素的自发分泌
Eur Neurol. 1980;19(3):198-206. doi: 10.1159/000115147.

引用本文的文献

1
A Critical Evaluation of Wet Biomarkers for Huntington's Disease: Current Status and Ways Forward.亨廷顿舞蹈症生物标志物的批判性评估:现状与未来发展方向
J Huntingtons Dis. 2018;7(2):109-135. doi: 10.3233/JHD-170273.
2
A 24-Hour Study of the Hypothalamo-Pituitary Axes in Huntington's Disease.亨廷顿舞蹈病下丘脑-垂体轴的24小时研究
PLoS One. 2015 Oct 2;10(10):e0138848. doi: 10.1371/journal.pone.0138848. eCollection 2015.
3
Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression.
全长亨廷顿蛋白水平通过影响胰岛素样生长因子 1 的表达来调节体重。
Hum Mol Genet. 2010 Apr 15;19(8):1528-38. doi: 10.1093/hmg/ddq026. Epub 2010 Jan 22.
4
Neuroendocrine disturbances in Huntington's disease.亨廷顿舞蹈病中的神经内分泌紊乱
PLoS One. 2009;4(3):e4962. doi: 10.1371/journal.pone.0004962. Epub 2009 Mar 25.
5
Studies of hypothalamic function in Huntington's chorea.亨廷顿舞蹈症下丘脑功能的研究。
J Neurol Neurosurg Psychiatry. 1981 May;44(5):414-8. doi: 10.1136/jnnp.44.5.414.
6
Twenty-four hour plasma levels of growth hormone and prolactin in Huntington's disease.亨廷顿舞蹈病患者生长激素和催乳素的24小时血浆水平
J Neurol Neurosurg Psychiatry. 1983 Dec;46(12):1134-7. doi: 10.1136/jnnp.46.12.1134.
7
Insulin-induced hypoglycaemia does not abolish chorea.胰岛素诱导的低血糖症并不能消除舞蹈病。
J Neurol Neurosurg Psychiatry. 1982 Dec;45(12):1169-70. doi: 10.1136/jnnp.45.12.1169-a.
8
Growth hormone and prolactin response to bromocriptine in patients with Huntington's chorea.亨廷顿舞蹈症患者对溴隐亭的生长激素和催乳素反应
J Neurol Neurosurg Psychiatry. 1978 Feb;41(2):135-9. doi: 10.1136/jnnp.41.2.135.