Durso R, Tamminga C A, Ruggeri S, Denaro A, Kuo S, Chase T N
J Neurol Neurosurg Psychiatry. 1983 Dec;46(12):1134-7. doi: 10.1136/jnnp.46.12.1134.
Since hypothalamic neural degeneration is thought to occur in individuals with Huntington's disease, anterior pituitary hormone secretion which is in part regulated by the hypothalamus, was postulated to be altered in patients with this disease. To test this proposal, nine females with Huntington's disease were matched with controls to participate in a 24-hour basal level study of growth hormone and prolactin concentration in plasma. Patients who were free from all centrally active medication for at least six months and normal volunteers had blood sampled at 30-minute intervals over 24 hours in a minimal stress environment. The results demonstrated that plasma levels of growth hormone were elevated throughout the 24-hour time period in Huntington's disease individuals. Despite the elevation, the mean growth hormone curve of the Huntington's disease group retained characteristics similar to the control curve throughout the 24-hour time. Basal 24-hour plasma prolactin concentrations in Huntington's disease patients showed no difference from those in control individuals.
由于人们认为下丘脑神经变性会发生在患有亨廷顿舞蹈症的个体中，而下丘脑部分调节的垂体前叶激素分泌，据推测在患有这种疾病的患者中会发生改变。为了验证这一推测，九名患有亨廷顿舞蹈症的女性与对照组进行匹配，以参与一项关于血浆中生长激素和催乳素浓度的24小时基础水平研究。至少六个月未服用所有中枢活性药物的患者以及正常志愿者，在最低压力环境下每隔30分钟采集一次血液样本，持续24小时。结果表明，在24小时时间段内，亨廷顿舞蹈症个体的血浆生长激素水平均有所升高。尽管有所升高，但亨廷顿舞蹈症组的平均生长激素曲线在整个24小时内仍保留与对照组曲线相似的特征。亨廷顿舞蹈症患者的24小时基础血浆催乳素浓度与对照组个体相比无差异。
