亨廷顿舞蹈病中的脂肪酸模式与葡萄糖耐量（作者译）

[Fatty acid patterns and glucose tolerance in Huntington's chorea (author's transl)].

作者信息

Schubotz R, Hausmann L, Kaffarnik H, Zehner J, Oepen H

出版信息

Res Exp Med (Berl). 1976 Jul 2;167(3):203-15. doi: 10.1007/BF01851645.

Abstract

Fatty acid patterns of plasma lipids and glucose-tolerance in Huntington's chorea. 25 patients with Huntington's chorea of various manifestation (9 predisposed symptomefree, 5 with light and 11 with severe manifestation) had studies of carbohydrate and lipid metabolism. These studies measured glucose-tolerance tests, insulin-, HGH-secretion, serum lipids and plasma fatty acid conposition of the cholesterylesters, triglycerides and phospholipids. The reactive insulin- but not HGH-levels were significantly raised, 32 % of the patients with Huntington's chorea had abnormal glucose-tolerance tests, compared with 3.2 % in a control group. Duration of symptoms correlated with higher cholesterol levels. Minor deviations were found in the fatty acid patterns in various lipid clases.

摘要

亨廷顿舞蹈病患者血浆脂质的脂肪酸模式与葡萄糖耐量。对25例具有不同表现的亨廷顿舞蹈病患者（9例有易患倾向但无症状，5例轻度表现，11例重度表现）进行了碳水化合物和脂质代谢研究。这些研究测量了葡萄糖耐量试验、胰岛素、生长激素分泌、血脂以及胆固醇酯、甘油三酯和磷脂的血浆脂肪酸组成。反应性胰岛素水平而非生长激素水平显著升高，32%的亨廷顿舞蹈病患者葡萄糖耐量试验异常，而对照组这一比例为3.2%。症状持续时间与较高的胆固醇水平相关。在各种脂质类别中发现脂肪酸模式存在轻微偏差。