Drozhzhin A P, Ibadova D N
Farmakol Toksikol. 1975 May-Jun;38(3):289-94.
The lengthening of the alkyl radical at the quaternary nitrogen atom (from -C2H5 to -C20H41) in the series of alkyltrimethylammonium compounds was found to lead to a gradually growing hydrophobicity of the compound. A change in the mechanism responsible for the myoparalytic action of the compound is due to a mounting degree of hydrophobicity. With the methyl group in the molecule of tetramethylammonium replaced with polyalicyclic radicals (bornyl, adamantyl) the compound, acting after a non-depolarizing type, possess a greater degree of hyrophobicity than do substances of the depolarizing type.
在烷基三甲基铵化合物系列中，季氮原子上烷基链的延长（从 -C2H5 到 -C20H41）会导致化合物疏水性逐渐增强。化合物致肌麻痹作用机制的改变是由于疏水性程度增加。在四甲基铵分子中的甲基被多脂环族基团（冰片基、金刚烷基）取代后，该化合物以非去极化型起作用，其疏水性程度比去极化型物质更高。
