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[快速起效的突触后非去极化型肌肉松弛剂的发展方向]

[Directions in the development of postsynaptic nondepolarizing muscle relaxants with rapidly developing action].

作者信息

Danilov A F, Zhabko E P, Fedorov Iu D

出版信息

Eksp Klin Farmakol. 1994 Jul-Aug;57(4):18-20.

PMID:7950774
Abstract

The experiments on unconscious cats have shown that the myoparalytic effect of postsynaptic non-depolarizing myorelaxants which have a trimethylammonium cationic group develops more rapidly than that of their triethylammonium analogues. The compound IEM-1213 is given as an example of a trimethylammonium derivative with the rigid structure of the molecule having an unusual rapidly developed effect.

摘要

对无意识猫的实验表明,具有三甲基铵阳离子基团的突触后非去极化肌松药的肌麻痹作用比其三乙铵类似物发展得更快。以化合物IEM - 1213为例,它是一种具有刚性分子结构且作用异常迅速的三甲基铵衍生物。

相似文献

1
[Directions in the development of postsynaptic nondepolarizing muscle relaxants with rapidly developing action].[快速起效的突触后非去极化型肌肉松弛剂的发展方向]
Eksp Klin Farmakol. 1994 Jul-Aug;57(4):18-20.
2
[The inhibition of synaptic acetylcholinesterase by postsynaptic muscle relaxants].[突触后肌肉松弛剂对突触乙酰胆碱酯酶的抑制作用]
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[A nondepolarizing muscle relaxant with rapidly developing and short-term action].一种具有快速起效和短效作用的非去极化肌松药。
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[The future directions in the search for postsynaptic muscle relaxants with rapidly developing and short-term action].[寻找具有快速起效和短效作用的突触后肌肉松弛剂的未来方向]
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[Role of the hydrophobicity of monoquaternary ammonium compounds in the mechanism of their curariform action].[单季铵化合物的疏水性在其箭毒样作用机制中的作用]
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[Decurarization using the cation-anion molecular interaction of a myorelaxant and its antagonist].[利用肌松药及其拮抗剂的阳离子-阴离子分子相互作用进行脱肌松作用]
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7
In search of new neuromuscular blocking drugs with quick onset and short duration of effect.寻找起效迅速、作用时间短的新型神经肌肉阻滞药物。
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[Postsynaptic nondepolarizing muscle relaxants in clinical practice].
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[Relationship between the effect of proserine on the action of myorelaxants and their proper anticholinesterase activity].[脯氨酸对肌松剂作用的影响与其适当的抗胆碱酯酶活性之间的关系]
Eksp Khir Anesteziol. 1969 Jan-Feb;14(1):59-64.