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[快速起效的突触后非去极化型肌肉松弛剂的发展方向]

[Directions in the development of postsynaptic nondepolarizing muscle relaxants with rapidly developing action].

作者信息

Danilov A F, Zhabko E P, Fedorov Iu D

出版信息

Eksp Klin Farmakol. 1994 Jul-Aug;57(4):18-20.

PMID:7950774
Abstract

The experiments on unconscious cats have shown that the myoparalytic effect of postsynaptic non-depolarizing myorelaxants which have a trimethylammonium cationic group develops more rapidly than that of their triethylammonium analogues. The compound IEM-1213 is given as an example of a trimethylammonium derivative with the rigid structure of the molecule having an unusual rapidly developed effect.

摘要

对无意识猫的实验表明,具有三甲基铵阳离子基团的突触后非去极化肌松药的肌麻痹作用比其三乙铵类似物发展得更快。以化合物IEM - 1213为例,它是一种具有刚性分子结构且作用异常迅速的三甲基铵衍生物。

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