Grokhovskiĭ S L, Gottikh B P, Zhuze A L
Bioorg Khim. 1992 Apr;18(4):570-83.
In search for compounds capable of forming covalent bonds with DNA AT-pair clusters, distamycin A and netropsin analogues containing DL-sarcolysin or platinum (II) atom at the N-terminus of the molecule were synthesized, as well as bis-netropsin and bis-distamycin in which two netropsin- or distamycin-like fragments are bound via a cis-diammineplatinum (II) residue. It is shown that these substances can be used for the DNA selective cleavage.
为了寻找能够与DNA AT碱基对簇形成共价键的化合物，合成了在分子N端含有DL-肌溶素或铂（II）原子的偏端霉素A和纺锤菌素类似物，以及双纺锤菌素和双偏端霉素，其中两个类似纺锤菌素或偏端霉素的片段通过顺式二胺铂（II）残基相连。结果表明，这些物质可用于DNA的选择性切割。
