Batra S C, Iosif C S
Department of Obstetrics and Gynecology, University Hospital, Lund, Sweden.
J Urol. 1992 Sep;148(3):935-8. doi: 10.1016/s0022-5347(17)36781-2.
The effect of one, 4 and 8 weeks of continuous estrogenization of rabbit on peroxidase (PO) activity and on both cytoplasmic and nuclear estrogen receptors was studied in the uterus, vagina, urethra and urinary bladder. Whereas the peroxidase activity in the urogenital tissue of untreated controls was near zero, after one week of estrogen treatment it increased very substantially in the uterus and vagina and much less dramatically in the urethra or urinary bladder. With continuation of estrogen treatment for 4 or 8 weeks the PO decreased by 80-90% in the uterus and vagina and by only 40% in the urethra. After one week of estrogen treatment the density of both cytosolic and nuclear estrogen receptors decreased by several fold in both the uterus and vagina, whereas it decreased by 30-50% in the urethra and bladder. The concentration of both cytosolic and nuclear receptors decreased further although less dramatically with continuing estrogen treatment, up to 8 weeks, in all tissues. These data suggest that although the general pattern of responses to estrogen showing an initial increase in PO followed by a reduction with continuing estrogen treatment is the same in all urogenital tissues, the responses seem to have a prolonged time scale in the case of lower urinary tract tissues. The quantitative aspect of the response generally corresponds with the density of estrogen receptors in the urogenital tissues.
研究了对兔子连续进行1周、4周和8周雌激素处理后，其子宫、阴道、尿道和膀胱中过氧化物酶（PO）活性以及细胞质和细胞核雌激素受体的变化。未处理对照组泌尿生殖组织中的过氧化物酶活性接近零，雌激素处理1周后，子宫和阴道中的过氧化物酶活性大幅增加，而尿道或膀胱中的增加幅度则小得多。随着雌激素处理持续4周或8周，子宫和阴道中的PO活性降低了80 - 90%，尿道中仅降低了40%。雌激素处理1周后，子宫和阴道中细胞质和细胞核雌激素受体的密度均下降了数倍，而尿道和膀胱中则下降了30 - 50%。随着雌激素处理持续至8周，所有组织中细胞质和细胞核受体的浓度均进一步下降，尽管降幅较小。这些数据表明，虽然所有泌尿生殖组织对雌激素反应的总体模式相同，即PO活性最初增加，随后随着雌激素处理的持续而降低，但下尿路组织的反应时间似乎更长。反应的定量方面通常与泌尿生殖组织中雌激素受体的密度相对应。
