Taguchi O, Cunha G R, Robboy S J
Am J Anat. 1986 Dec;177(4):473-80. doi: 10.1002/aja.1001770405.
An autoradiographic study of nuclear estrogen binding was performed in developing human urogenital sinuses and vaginas derived from first and second trimester specimens. Nuclear estrogen binding was detected in all specimens greater than or equal to 10 weeks of gestation within mesenchymal cells. Nuclear labelling within epithelium was observed only in those specimens whose development and differentiation was advanced. Thus, mesenchyme appears to be the initial estrogen target tissue within the developing human vagina and may play a fundamental role in estrogen-induced teratogenesis of the human genital tract.
对取自孕早期和孕中期标本的发育中的人类泌尿生殖窦和阴道进行了核雌激素结合的放射自显影研究。在所有妊娠10周及以上标本的间充质细胞中检测到核雌激素结合。仅在那些发育和分化进程较高级的标本的上皮细胞中观察到核标记。因此，间充质似乎是发育中的人类阴道内最初的雌激素靶组织，并且可能在雌激素诱导的人类生殖道致畸过程中发挥重要作用。
