近交系大鼠的遗传学研究。VI. 混合淋巴细胞反应、血清学定义抗原（Ag-B、Ag-C）与对聚（谷氨酸52-赖氨酸33-酪氨酸15）免疫反应的连锁关系。

Genetic studies in inbred rats. VI. Linkage relationships of mixed lymphocyte reactivity, serologically defined antigens (Ag-B, Ag-C) and the immune response to poly(Glu52Lys33Tyr15).

作者信息

Shonnard J W, Cramer D V, Poloskey P E, Davis B K, Gill T J

出版信息

J Immunogenet. 1976 Feb;3(1):61-70. doi: 10.1111/j.1744-313x.1976.tb00556.x.

DOI:10.1111/j.1744-313x.1976.tb00556.x

Abstract

The Ag-B allotype, mixed lymphocyte reactivity (MLR) and the immune response to poly(Glu52Lys33Tyr15) were assayed in male rats from the F2 hybrid and two backcross generations of the F344 and DA strains in order to investigate the structure of the rat major histocompatibility complex. No disparity between Ag-B type and mixed lymphocyte reactivity was found in 263 animals. The immune response to poly(Glu52Lys33Tyr15) was closely linked to the Ag-B locus, and both antibody production and the delayed hypersensitivity response were under polygenic control. These results suggest that the genetic loci which determine these responses in the rat are closely linked and that recombinational events between the Ag-B and MLR loci are infrequent.

摘要

为了研究大鼠主要组织相容性复合体的结构，对F2杂种以及F344和DA品系的两个回交世代的雄性大鼠进行了Ag - B同种异型、混合淋巴细胞反应（MLR）以及对聚（Glu52Lys33Tyr15）的免疫反应检测。在263只动物中未发现Ag - B型与混合淋巴细胞反应之间存在差异。对聚（Glu52Lys33Tyr15）的免疫反应与Ag - B基因座紧密相连，并且抗体产生和迟发型超敏反应均受多基因控制。这些结果表明，在大鼠中决定这些反应的基因座紧密相连，并且Ag - B和MLR基因座之间的重组事件很少见。