Martin P, Hopkinson-Woolley J, McCluskey J
Department of Human Anatomy, Oxford University, U.K.
Prog Growth Factor Res. 1992;4(1):25-44. doi: 10.1016/0955-2235(92)90003-z.
The healing of an adult skin lesion is a well studied but complex affair of some considerable clinical interest. Endogenous growth factors, including the EGF, FGF, PDGF and TGF beta families, are released at the wound site and presumed to be a necessary part of the natural wound healing machinery. Moreover, members of each of these families have been shown to enhance healing if added exogenously to a wound site. In this review we shall briefly discuss what is known about the mechanics and cell biology of adult wound healing, describe the normal cellular source of growth factors during the healing process and, with reference to their known capacities in tissue culture, speculate as to how particular growth factors might be able to enhance healing.
成人皮肤损伤的愈合是一个研究充分但颇为复杂且具有相当临床意义的过程。内源性生长因子，包括表皮生长因子（EGF）、成纤维细胞生长因子（FGF）、血小板衍生生长因子（PDGF）和转化生长因子β（TGF-β）家族，在伤口部位释放，并被认为是自然伤口愈合机制的必要组成部分。此外，这些家族中的每个成员若外源性添加到伤口部位，都已被证明可促进愈合。在本综述中，我们将简要讨论已知的成人伤口愈合的力学和细胞生物学知识，描述愈合过程中生长因子的正常细胞来源，并参考它们在组织培养中的已知能力，推测特定生长因子如何能够促进愈合。
