皮质酮对大鼠肾（钠+钾）-三磷酸腺苷酶mRNA水平的调节
Regulation of rat renal (Na(+) + K+)-adenosine triphosphatase mRNA levels by corticosterone.
作者信息
Klein L E, Lo C S
机构信息
Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
出版信息
Experientia. 1992 Aug 15;48(8):768-73. doi: 10.1007/BF02124300.
PMID:1325370
Abstract
We investigated the mechanisms for glucocorticoid regulation of rat renal NaK-ATPase activity. Our findings suggest that the magnitudes of corticosterone-induced increases in alpha 1 mRNA and beta 1 mRNA levels are similar in the kidney of the adult adrenalectomized rats. The results also suggest that corticosterone restores NaK-ATPase activity in adrenalectomized rats prior to any enhanced sodium delivery.
摘要
我们研究了糖皮质激素调节大鼠肾钠钾-ATP酶活性的机制。我们的研究结果表明，在成年去肾上腺大鼠的肾脏中，皮质酮诱导的α1 mRNA和β1 mRNA水平升高幅度相似。结果还表明，在任何钠输送增加之前，皮质酮就能恢复去肾上腺大鼠的钠钾-ATP酶活性。
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