Epstein F H, Charney A N, Silva P
Yale J Biol Med. 1978 May-Jun;51(3):365-72.
An increase in Na-K-ATPase in kidney homogenates usually accompanies compensatory renal hypertrophy. While it may be evident in both the cortex and medulla of the kidney, it is most marked in the outer medulla and may be present only in that region. The increase in enzyme activity does not depend on an intact adrenal cortex and can be elicited in the absence of adrenal glucocorticoids. It is not seen in the form of renal hypertrophy produced by potassium depletion, in which the transport of sodium and potassium by the kidney is not increased. When present in compensatory renal growth, the enzyme change is correlated with an increase in the reabsorption of sodium, or the excretion of potassium, or both, per unit of renal tissue. It proceeds in the presence of either, but not in the absence of both.
肾脏匀浆中钠钾ATP酶的增加通常伴随着代偿性肾肥大。虽然在肾脏皮质和髓质中都可能很明显，但在外髓质中最为显著，且可能仅存在于该区域。酶活性的增加不依赖于完整的肾上腺皮质，在没有肾上腺糖皮质激素的情况下也可引发。在钾缺乏引起的肾肥大形式中未观察到这种增加，钾缺乏时肾脏对钠和钾的转运并未增加。当存在于代偿性肾脏生长中时，酶的变化与每单位肾组织中钠重吸收增加、钾排泄增加或两者都增加相关。在二者之一存在的情况下会发生这种变化，但在二者都不存在的情况下则不会。
