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UCT4B, a new antitumor antibiotic with topoisomerase II mediated DNA cleavage activity, from Streptomyces sp.

作者信息

Kawada S Z, Yamashita Y, Uosaki Y, Gomi K, Iwasaki T, Takiguchi T, Nakano H

机构信息

Kyowa Hakko Kogyo Co., Ltd., Technical Research Laboratories, Yamaguchi, Japan.

出版信息

J Antibiot (Tokyo). 1992 Jul;45(7):1182-4. doi: 10.7164/antibiotics.45.1182.

DOI:10.7164/antibiotics.45.1182
PMID:1325436
Abstract
摘要

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1
UCT4B, a new antitumor antibiotic with topoisomerase II mediated DNA cleavage activity, from Streptomyces sp.来自链霉菌属的具有拓扑异构酶II介导的DNA切割活性的新型抗肿瘤抗生素UCT4B
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[Antitumor agents targeting mammalian topoisomerases].[靶向哺乳动物拓扑异构酶的抗肿瘤药物]
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Chrolactomycin, a novel antitumor antibiotic produced by Streptomyces sp.氯乳霉素,一种由链霉菌属产生的新型抗肿瘤抗生素。
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Mapping of DNA topoisomerase II poisons (etoposide, clerocidin) and catalytic inhibitors (aclarubicin, ICRF-187) to four distinct steps in the topoisomerase II catalytic cycle.将DNA拓扑异构酶II毒素(依托泊苷、clerocidin)和催化抑制剂(阿柔比星、ICRF-187)映射到拓扑异构酶II催化循环的四个不同步骤。
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Induction of mammalian DNA topoisomerase I and II mediated DNA cleavage by saintopin, a new antitumor agent from fungus.新型真菌抗肿瘤剂圣托品诱导哺乳动物DNA拓扑异构酶I和II介导的DNA裂解
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Genomic sites of topoisomerase II activity determined by comparing DNA breakage enhanced by three distinct poisons.通过比较三种不同毒物增强的DNA断裂来确定拓扑异构酶II活性的基因组位点。
J Mol Biol. 1999 Jan 15;285(2):545-54. doi: 10.1006/jmbi.1998.2330.
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Cytotoxic antibiotic angucyclines and actinomycins from the Streptomyces sp. XZHG99T.来自链霉菌 XZHG99T 的细胞毒性抗生素安格鲁霉素和放线菌素。
J Antibiot (Tokyo). 2018 Nov;71(12):1018-1024. doi: 10.1038/s41429-018-0096-1. Epub 2018 Aug 29.

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Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage.克勒罗菌素选择性修饰回旋酶 - DNA门以诱导不可逆和可逆的DNA损伤。
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Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action.Clerocidin通过其环氧化物功能使DNA烷基化:作用机制微调的证据。
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The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage.拓扑异构酶II毒药clerocidin使DNA未配对的鸟嘌呤烷基化:对DNA切割不可逆刺激的影响。
Nucleic Acids Res. 2001 Oct 15;29(20):4224-30. doi: 10.1093/nar/29.20.4224.