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特喷替辛和ECT4B，链霉菌产生的新型靶向拓扑异构酶II的抗肿瘤抗生素家族：产生菌、发酵及大规模纯化

Terpentecin and ECT4B, new family of topoisomerase II targeting antitumor antibiotics produced by Streptomyces: producing organism, fermentation and large scale purification.

作者信息

Kawada S, Yamashita Y, Ochiai K, Ando K, Iwasaki T, Takiguchi T, Nakano H

机构信息

Kyowa Hakko Kogyo Co., Ltd., Technical Research Laboratories, Yamaguchi, Japan.

出版信息

J Antibiot (Tokyo). 1995 Mar;48(3):211-6. doi: 10.7164/antibiotics.48.211.

DOI:10.7164/antibiotics.48.211
PMID:7730154
Abstract

Terpentecin and UCT4B are new family of antitumor antibiotics with topoisomerase II mediated DNA cleavage activity. Based on the taxonomic studies, the producing strain S-464 was identified as Streptomyces sp. This strain is different from Kitasatosporia griseola which had been identified as the terpentecin-producing strain in 1988. Fermentation studies showed that natural nitrogen sources supported higher titer of terpentecin, and the synthetic medium with inorganic nitrogen sources supported selective production of UCT4B. An improved isolation method was developed for the large scale purification of terpentecin.

摘要

特喷替星和UCT4B是具有拓扑异构酶II介导的DNA切割活性的新型抗肿瘤抗生素家族。基于分类学研究，产生菌株S-464被鉴定为链霉菌属。该菌株不同于1988年被鉴定为产生特喷替星的菌株灰北里孢菌。发酵研究表明，天然氮源能支持更高的特喷替星效价，而含有无机氮源的合成培养基能支持UCT4B的选择性产生。开发了一种改进的分离方法用于特喷替星的大规模纯化。

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