Tortorella C, Ottolenghi A, Moretti A M, Jirillo E, Antonaci S
University of Bari Medical Faculty, Policlinico, Italy.
Immunopharmacol Immunotoxicol. 1992;14(3):421-37. doi: 10.3109/08923979209005402.
Several studies outline the imbalance of phagocyte functions in chronic obstructive pulmonary disease (COPD). In this regard, here, we have assessed either monocyte- and polymorphonuclear cell (PMN)-mediated chemotactic, phagocytic and killing capacities or PMN-triggered metabolic pathway in a group of COPD patients before and at different times after thymostimulin administration. Before therapy, an increase of O2-generation and a decrease of myeloperoxidase release were found in these individuals when compared to controls. Moreover, a reduction of either PMN-mediated chemotaxis and killing or monocyte chemotactic capacities was observed. By contrast, no differences were seen in terms of beta-glucuronidase release, monocyte-mediated killing and PMN or monocyte phagocytic function. During a one-year monitoring following immunotherapy, O2- production and myeloperoxidase activity fell within normal values, while phagocyte functional capacities were unaffected by such a treatment. Furthermore, COPD subjects exhibited a significant improvement of their clinical status as assessed during a one-year followup. All together, these findings suggest a potential role for thymostimulin in the treatment of COPD patients.
多项研究概述了慢性阻塞性肺疾病（COPD）中吞噬细胞功能的失衡。在这方面，我们在此评估了一组COPD患者在给予胸腺刺激素之前及之后不同时间的单核细胞和多形核细胞（PMN）介导的趋化、吞噬和杀伤能力，以及PMN触发的代谢途径。治疗前，与对照组相比，这些个体中发现O2生成增加，髓过氧化物酶释放减少。此外，观察到PMN介导的趋化和杀伤或单核细胞趋化能力降低。相比之下，在β-葡萄糖醛酸酶释放、单核细胞介导的杀伤以及PMN或单核细胞吞噬功能方面未发现差异。在免疫治疗后的一年监测期间，O2产生和髓过氧化物酶活性降至正常范围内，而吞噬细胞功能能力不受该治疗的影响。此外，在一年的随访中评估发现，COPD患者的临床状况有显著改善。总之，这些发现表明胸腺刺激素在治疗COPD患者中具有潜在作用。
