Polignano A, Tortorella C, Venezia A, Jirillo E, Antonaci S
Department of Internal Medicine, University of Bari Medical Faculty, Italy.
Cytobios. 1994;80(322):145-53.
Conflicting results have been reported on polymorphonuclear (PMN) cell responsiveness during senescence. Consequently, neutrophil absolute numbers and PMN-mediated chemotaxis, phagocytosis, killing and superoxide anion (O2-) generation in healthy aged volunteers divided into different groups according to increasing age criteria, were investigated and evaluated. Data provide evidence that absolute amounts of PMN cells declined in a significant manner in donors over 85 years old only when compared with young subjects. On the contrary, regardless of age, the aged individuals exhibited a significant impairment of PMN chemotactic, phagocytic and killing functional capacities. Finally, formyl-methionyl-leucyl-phenylanaline (FMLP)-triggered O2- release was reduced in all elderly groups, while depression of O2- production was seen in subjects between the age of 86 and 104 years using phorbol 12-myristate 13-acetate (PMA) as agonist. These findings indicate that an imbalance in the PMN cell immune reactivity occurs throughout the senescence process.
关于衰老过程中多形核（PMN）细胞反应性的报道结果相互矛盾。因此，我们对根据年龄增长标准分为不同组别的健康老年志愿者的中性粒细胞绝对数量以及PMN介导的趋化性、吞噬作用、杀伤作用和超氧阴离子（O2-）生成进行了研究和评估。数据表明，仅在与年轻受试者相比时，85岁以上供体的PMN细胞绝对数量才显著下降。相反，无论年龄大小，老年个体的PMN趋化、吞噬和杀伤功能能力均有显著损害。最后，所有老年组中，甲酰甲硫氨酰亮氨酰苯丙氨酸（FMLP）触发的O2-释放均减少，而使用佛波酯12-肉豆蔻酸酯13-乙酸酯（PMA）作为激动剂时，86至104岁受试者的O2-生成受到抑制。这些发现表明，在整个衰老过程中PMN细胞免疫反应性会出现失衡。
