Zhou Q, Zhang H, Pang X, Yang J, Tain Z, Wu Z, Yang Z
Department of Thoracic Cardiovascular Surgery, First Affiliated Hospital, West China University of Medical Sciences, Sichuan.
J Surg Oncol. 1992 Sep;51(1):22-5. doi: 10.1002/jso.2930510108.
Serial changes in serum gastrin level were detected by radioimmunoassay in 58 lung cancer patients before and after operation. In comparing these tests with those of 40 cases of noncancerous thoracic lesions and 151 normal adults, the serum gastrin from lung cancer patients is significantly higher than that of noncancerous thoracic lesions and normal individuals (P less than 0.01). The gastrin level is closely related to stage of cancer, size of primary tumor, presence of lymph node metastasis, and type of histological classification. The serum gastrin was found to decrease gradually after the removal of the tumor and to return to normal on the 14th postoperative day. Those patients whose serum gastrin level can return to normal on the 14th postoperative day will have a good prognosis; if not, their prognosis will be very poor. These results suggest that serum from patients with lung cancer contains a high concentration of gastrin that can help differentiate benign from malignant thoracic lesions and evaluate prognosis of patients with lung cancer. Therefore, the cause of high serum gastrin in patients with lung cancer is likely due to the gastrin-producing property of the lung cancer cells.
采用放射免疫分析法检测了58例肺癌患者手术前后血清胃泌素水平的系列变化。将这些检测结果与40例非癌性胸部病变患者及151例正常成年人的检测结果进行比较，发现肺癌患者的血清胃泌素水平显著高于非癌性胸部病变患者和正常个体（P<0.01）。胃泌素水平与癌症分期、原发肿瘤大小、淋巴结转移情况及组织学分类类型密切相关。发现肿瘤切除后血清胃泌素水平逐渐下降，并在术后第14天恢复正常。术后第14天血清胃泌素水平能恢复正常的患者预后良好；若不能恢复正常，则预后很差。这些结果表明，肺癌患者血清中含有高浓度的胃泌素，这有助于鉴别胸部良性与恶性病变，并评估肺癌患者的预后。因此，肺癌患者血清胃泌素水平升高的原因可能是肺癌细胞具有产生胃泌素的特性。
