Roussos Anastasios, Philippou Nikiforos, Gourgoulianis Konstantinos I
9th Department of Pulmonary Medicine, SOTIRIA Chest Diseases Hospital, Athens, Greece.
World J Gastroenterol. 2003 Jan;9(1):5-8. doi: 10.3748/wjg.v9.i1.5.
In the past few years, a variety of extradigestive disorders, including cardiovascular, skin, rheumatic and liver diseases, have been associated with Helicobacter pylori (H. pylori) infection. The activation of inflammatory mediators by H. pylori seems to be the pathogenetic mechanism underlying the observed associations. The present review summarizes the current literature, including our own studies, concerning the association between H. pylori infection and respiratory diseases. A small number of epidemiological and serologic, case-control studies suggest that H. pylori infection may be associated with the development of chronic bronchitis. A frequent coexistence of pulmonary tuberculosis and H. pylori infection has also been found. Moreover, recent studies have shown an increased H. pylori seroprevalence in patients with bronchiectasis and in those with lung cancer. On the other hand, bronchial asthma seems not to be related with H. pylori infection. All associations between H. pylori infection and respiratory diseases are primarily based on case-control studies, concerning relatively small numbers of patients. Moreover, there is a lack of studies focused on the pathogenetic link between respiratory diseases and H. pylori infection. Therefore, we believe that larger studies should be undertaken to confirm the observed results and to clarify the underlying pathogenetic mechanisms.
在过去几年中，包括心血管疾病、皮肤病、风湿性疾病和肝脏疾病在内的多种消化系统外疾病已被发现与幽门螺杆菌（H. pylori）感染有关。幽门螺杆菌激活炎症介质似乎是所观察到的这些关联背后的发病机制。本综述总结了包括我们自己的研究在内的关于幽门螺杆菌感染与呼吸道疾病之间关联的现有文献。少数流行病学和血清学病例对照研究表明，幽门螺杆菌感染可能与慢性支气管炎的发生有关。还发现肺结核与幽门螺杆菌感染经常并存。此外，最近的研究表明，支气管扩张症患者和肺癌患者中幽门螺杆菌血清阳性率有所增加。另一方面，支气管哮喘似乎与幽门螺杆菌感染无关。幽门螺杆菌感染与呼吸道疾病之间的所有关联主要基于病例对照研究，涉及的患者数量相对较少。此外，缺乏专注于呼吸道疾病与幽门螺杆菌感染之间发病机制联系的研究。因此，我们认为应该开展更大规模的研究来证实所观察到的结果，并阐明潜在的发病机制。
