Hatab M A, Whittaker P A
Department of Biology, Maynooth College, Kildare, Ireland.
Antonie Van Leeuwenhoek. 1992 Apr;61(3):207-19. doi: 10.1007/BF00584227.
The isolation of several respiration deficient mutants of the pathogenic yeast Candida albicans is described. These show greatly reduced respiration rates, loss of cytochromes aa3 and b, and reduced growth rates. All of the mutants had lost the ability to assimilate a wide range of carbon sources. Ultrastructural studies showed reduced development of mitochondrial cristae in the mutants. The mutants can be divided into three classes depending on their respiration responses to the addition of cyanide.
本文描述了致病性酵母白色念珠菌几种呼吸缺陷型突变体的分离情况。这些突变体的呼吸速率大幅降低，细胞色素aa3和b缺失，生长速率也降低。所有突变体都丧失了同化多种碳源的能力。超微结构研究表明，突变体中线粒体嵴的发育减少。根据它们对添加氰化物的呼吸反应，这些突变体可分为三类。
