白色念珠菌中的杂合性与分离现象
Heterozygosity and segregation in Candida albicans.
作者信息
Whelan W L, Partridge R M, Magee P T
出版信息
Mol Gen Genet. 1980;180(1):107-13. doi: 10.1007/BF00267358.
PMID:7003306
Abstract
Strain FC18 of the pathogenic yeast Candida albicans is heterozygous at a gene required for synthesis of methionine and cysteine, and yields auxotrophic derivatives by induced mitotic segregation. Derivatives of FC18 are heterozygous at other genes. Genetic analysis of C. albicans is feasible using induced mitotic recombination.
摘要
致病性白色念珠菌菌株FC18在甲硫氨酸和半胱氨酸合成所需的一个基因处是杂合的，并通过诱导有丝分裂分离产生营养缺陷型衍生物。FC18的衍生物在其他基因处也是杂合的。利用诱导有丝分裂重组对白色念珠菌进行遗传分析是可行的。
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