Coombes A G, Meikle M C
Department of Pharmaceutical Sciences, University of Nottingham, University Park, UK.
Clin Mater. 1994;17(1):35-67. doi: 10.1016/0267-6605(94)90046-9.
The potential of resorbable synthetic polymers derived from the poly(alpha-hydroxy acids), poly(lactide) and poly(glycolide), to fulfill a role as bone graft substitutes is reviewed. The various elements of the relationship between the degradation behaviour of resorbable implants and polymer synthesis and chain structure, implant morphology, processing and dimensions have been defined. The production of resorbable polymeric implants has been extensively documented so as to provide a wide basis for selection of an appropriate manufacturing technique. The key requirement of implant dimensional stability over the early stages of bone healing is emphasised so as to provide a stable surface on which osteoblasts and/or their precursor cells may migrate and secrete bone matrix. Minimisation of the content of slow resorbing polymers such as poly(L-lactide) is recommended, consistent with retention of an adequate implant degradation characteristic. The review concludes with a summary of alternative resorbable polymers such as the polyphosphazines which are interesting candidate materials for bone repair and reconstruction.
本文综述了源自聚（α-羟基酸）、聚丙交酯和聚乙交酯的可吸收合成聚合物作为骨移植替代物的潜力。已明确了可吸收植入物的降解行为与聚合物合成及链结构、植入物形态、加工工艺和尺寸之间关系的各个要素。可吸收聚合物植入物的生产已有大量文献记载，以便为选择合适的制造技术提供广泛依据。强调了植入物在骨愈合早期阶段尺寸稳定性的关键要求，以便提供一个稳定的表面，使成骨细胞和/或其前体细胞能够在其上迁移并分泌骨基质。建议尽量减少聚（L-丙交酯）等缓慢吸收聚合物的含量，同时保持足够的植入物降解特性。综述最后总结了其他可吸收聚合物，如聚磷腈，它们是骨修复和重建中有趣的候选材料。
