Bruaire J P, Ducroix J P, Eb F, Smail A, Cohen G, Orfila J, Baillet J
Service de Médecine interne, Hôpital Nord, CHRU, Amiens.
Presse Med. 1992 Jun 20;21(23):1064-9.
Among the atypical pneumonias observed between March 1990 and March 1991, 6 were diagnosed as being caused by Chlamydia pneumoniae of the TWAR strain. The serological diagnosis was obtained by a microimmunofluorescence test. All 6 patients had anti-TWAR antibody levels higher than 512; they were treated with a macrolide administered by the oral route and were cured without sequelae or recurrences. Four cases received a ten day course of roxithromycin 300 mg/day and one case received erythromycin 2 g/day also for 10 days. The sixth case received a short course of azithromycin 500 mg once daily for three days. In 2 other patients presenting with clinical and radiological signs of pneumonia the diagnosis of C. pneumoniae infection could not be made despite an antibody level equal or higher than 512, since the serological results showed cross-reactions between C. pneumoniae, C. trachomatis and C. psittaci antibody responses.
在1990年3月至1991年3月间观察到的非典型肺炎病例中，有6例被诊断为由TWAR株肺炎衣原体引起。血清学诊断通过微量免疫荧光试验获得。所有6例患者的抗TWAR抗体水平均高于512；他们接受了口服大环内酯类药物治疗，治愈后无后遗症或复发。4例患者接受了为期10天、每天300毫克罗红霉素的疗程，1例患者接受了同样为期10天、每天2克红霉素的治疗。第6例患者接受了为期3天、每天一次500毫克阿奇霉素的短疗程治疗。在另外2例有肺炎临床和影像学表现的患者中，尽管抗体水平等于或高于512，但由于血清学结果显示肺炎衣原体、沙眼衣原体和鹦鹉热衣原体抗体反应之间存在交叉反应，故无法做出肺炎衣原体感染的诊断。
