Lagnese M, Daar E S, Christenson P, Rieg G
Division of HIV Medicine and Infectious Diseases at Harbor-UCLA Medical Center, Los Angeles, CA, USA.
Int J STD AIDS. 2011 Aug;22(8):463-4. doi: 10.1258/ijsa.2011.010551. Epub 2011 Jul 8.
Herpes simplex virus type 2 (HSV-2) HIV co-infection is common and associated with increased risk of HIV transmission. HSV-2 seroprevalence was assessed on stored samples from baseline and one year follow-up from 81 patients identified with acute HIV infection and 81 age-matched chronically infected men. HSV-2 seroprevalence at baseline was lower for those with acute rather than chronic HIV-infection, 51.9 versus 71.6% (P = 0.01); relative risk 0.72 (95% confidence interval [CI] 0.57-0.92). Since HSV-2 seroprevalence is lower in those newly HIV-infected, the diagnosis of early HIV infection may allow for counselling to reduce subsequent HSV-2 acquisition.
2型单纯疱疹病毒（HSV-2）与HIV合并感染很常见，且与HIV传播风险增加有关。对81例确诊为急性HIV感染的患者以及81例年龄匹配的慢性感染男性的基线和一年随访的储存样本进行了HSV-2血清阳性率评估。急性HIV感染患者基线时的HSV-2血清阳性率低于慢性HIV感染患者，分别为51.9%和71.6%（P = 0.01）；相对风险为0.72（95%置信区间[CI] 0.57 - 0.92）。由于新感染HIV者的HSV-2血清阳性率较低，早期HIV感染的诊断可能有助于进行咨询，以减少后续HSV-2感染。
