Hokin-Neaverson M, Burckhardt W A, Jefferson J W
Res Commun Chem Pathol Pharmacol. 1976 May;14(1):117-26.
A significant mean increase of 18% in erythrocyte sodium pump activity (p less than 0.01, t test) was observed during lithium treatment, as compared with the activity before lithium treatment was started, in a group of 20 patients who were treated with lithium therapy for a variety of psychiatric conditions. The mean level of erythrocyte membrane ouabain-sensitive ATPase activity in a group of 35 subjects who were receiving lithium therapy was significantly higher than that of a different group of 38 subjects who were not receiving lithium therapy (p less than 0.005, t test). These observations may offer a biochemical mode of action for lithium in the treatment of bipolar affective disorder, since a deficiency of sodium pump activity has been shown to be associated with that disorder.
在一组因各种精神疾病接受锂盐治疗的20名患者中，与开始锂盐治疗前的活性相比，观察到锂盐治疗期间红细胞钠泵活性平均显著增加了18%（p<0.01，t检验）。一组接受锂盐治疗的35名受试者的红细胞膜哇巴因敏感ATP酶活性平均水平显著高于另一组未接受锂盐治疗的38名受试者（p<0.005，t检验）。这些观察结果可能为锂盐治疗双相情感障碍提供一种生化作用模式，因为已表明钠泵活性缺乏与该疾病有关。
