尝试证明盐酸米安色林对红细胞钠钾ATP酶活性和环磷酸腺苷浓度的体内作用。
Attempt to demonstrate an in vivo effect of mianserin hydrochloride on erythrocyte Na+-K+-ATPase activity and cyclic AMP concentration.
作者信息
Naylor G S, Buckley D E, Boardman L J, Smith A H, Moody J P
出版信息
Br J Clin Pharmacol. 1978;5 Suppl 1(Suppl 1):49S-51S.
Abstract
- There is evidence that erythrocyte Na+-K+-ATPase activity and erythrocyte cyclic AMP change on recovery from a depressive illness. Mianserin is a recently introduced antidepressant but its mode of action is unknown. The present study was therefore designed to investigate in vivo the effect of mianserin on erythrocyte Na+-K+-ATPase and cyclic AMP. 2. Biochemical estimations were made on blood from depressed patients before beginning either mianserin or matched placebo treatment, after 1 week, and again after 2 weeks' treatment. 3. Neither the erythrocyte Na+-K+-ATPase, nor the erythrocyte cyclic AMP concentration, changed significantly in either the mianserin- or the placebo-treated group. 4. The study sheds no light on the possible mechanism of action of mianserin.
摘要
- 有证据表明，抑郁症康复后红细胞钠钾ATP酶活性和红细胞环磷酸腺苷会发生变化。米安色林是一种最近推出的抗抑郁药，但其作用方式尚不清楚。因此，本研究旨在体内研究米安色林对红细胞钠钾ATP酶和环磷酸腺苷的影响。2. 在开始米安色林或匹配的安慰剂治疗前、治疗1周后以及治疗2周后，对抑郁症患者的血液进行生化评估。3. 在米安色林治疗组和安慰剂治疗组中，红细胞钠钾ATP酶和红细胞环磷酸腺苷浓度均未发生显著变化。4. 该研究未能揭示米安色林可能的作用机制。
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