Guo Y
Institute of Urology, Beijing Medical University.
Zhonghua Yi Xue Za Zhi. 1992 Apr;72(4):213-5, 254.
The characteristics of one of a group of monoclonal antibodies named BIU-H6 are reported. Using McAb BIU-H6, by ABC-immunohistochemical staining directed against 34 bladder cancers and 5 normal bladders. It was found that BIU-H6 does not react with normal bladder epithelial and adenocarcinoma of the bladder, but with transitional cell carcinoma, squamous cell carcinoma and CIS of the bladder. The staining characters were variant according to the different grade/stage of the cancer. The result shows that BIU-H6 antigen is a tumor associated antigen of poorly differentiated and invasive carcinoma of the bladder.
报道了一组名为BIU-H6的单克隆抗体之一的特性。使用单克隆抗体BIU-H6，通过针对34例膀胱癌和5例正常膀胱的ABC免疫组织化学染色。发现BIU-H6与正常膀胱上皮和膀胱腺癌无反应，但与膀胱移行细胞癌、鳞状细胞癌和原位癌有反应。染色特征根据癌症的不同分级/分期而有所不同。结果表明，BIU-H6抗原是低分化和浸润性膀胱癌的肿瘤相关抗原。
