Huland E, Arndt R, Huland H
Cancer Res. 1986 May;46(5):2488-9.
Human transitional cell carcinoma of the bladder was successfully transplanted into the bladder of the NMRI-nu/nu mouse. Transplantation of a single-cell suspension from a human Grade II transitional cell carcinoma had an acceptance rate of 33%. The tumors showed invasive growth and could be identified by an anti-human monoclonal antibody. This tumor model can be valuable as an in vivo test system for the local use of cytotoxic agents and monoclonal antibodies in diagnosis of and therapy for human bladder carcinoma.
人膀胱移行细胞癌成功移植到NMRI-nu/nu小鼠的膀胱中。来自人II级移行细胞癌的单细胞悬液移植成功率为33%。肿瘤呈浸润性生长，可用抗人单克隆抗体进行识别。该肿瘤模型作为一种体内测试系统，对于细胞毒性药物和单克隆抗体在人膀胱癌诊断和治疗中的局部应用可能具有重要价值。
