Lesher J L
Department of Dermatology, Medical College of Georgia, Augusta.
Dermatol Clin. 1992 Oct;10(4):799-805.
This article, rather than presenting an overview of all available antifungal agents, has provided an update on new information about older agents, as well as evolving information about new agents, including those currently undergoing clinical trials. Among the azoles, ketoconazole will continue to be used as a major antifungal agent in dermatology, but one must keep up with its side effects and drug interactions. The place of the new triazole fluconazole in the treatment of cutaneous fungal infections needs to be clarified by additional controlled studies. Other agents on the horizon which are still undergoing investigation include itraconazole, which should be especially useful for dermatophyte (including tinea unguium) and candidal infections, sporotrichosis, and unusual infections such as aspergillosis and phaeohyphomycosis; and terbinafine, a member of the new class of antifungals called allylamines, which is an orally and topically active fungicidal agent that should be very useful for all types of dermatophyte infections. Research continues into the effectiveness of members of other classes of antifungals, including piritetrate, cilofungin, and amorolfine. In the 1990s, dermatologists should have safer, more effective antifungal agents for treating cutaneous fungal infections.
本文并未对所有可用的抗真菌药物进行概述，而是提供了有关旧有药物的新信息更新，以及有关新药物的不断发展的信息，包括那些目前正在进行临床试验的药物。在唑类药物中，酮康唑将继续作为皮肤科的主要抗真菌药物使用，但必须密切关注其副作用和药物相互作用。新型三唑类药物氟康唑在皮肤真菌感染治疗中的地位需要通过更多对照研究加以明确。即将出现的仍在研究中的其他药物包括伊曲康唑，它对皮肤癣菌（包括甲癣）和念珠菌感染、孢子丝菌病以及曲霉病和暗色丝孢霉病等不常见感染尤其有用；还有特比萘芬，它是新一类抗真菌药物烯丙胺类的成员，是一种口服和外用均有活性的杀真菌剂，对所有类型的皮肤癣菌感染都应该非常有用。对其他类抗真菌药物成员，包括吡硫翁锌、西洛芬净和阿莫罗芬的有效性研究仍在继续。在20世纪90年代，皮肤科医生将拥有更安全、更有效的抗真菌药物用于治疗皮肤真菌感染。
