Ina Y, Takada K, Sato T, Yamamoto M, Noda M, Morishita M
Second Department of Internal Medicine, Nagoya City University Medical School, Japan.
Chest. 1992 Oct;102(4):1128-33. doi: 10.1378/chest.102.4.1128.
We determined levels of soluble interleukin 2 receptors (IL-2R) in patients with sarcoidosis and further examined their origin. Thirty-nine patients with sarcoidosis and 18 healthy control subjects were studied. Soluble IL-2R levels in serum were significantly higher (p < 0.01) in sarcoidosis than in control subjects. In sarcoidosis, levels of soluble IL-2R in serum were significantly higher (p < 0.05) in patients with active disease than those with inactive disease and were significantly (p < 0.01) correlated with serum angiotensin-converting enzyme (ACE) levels. IL-2R expression on monocytes and alveolar macrophages (AMs) was significantly (p < 0.01) increased in patients with sarcoidosis as compared with control subjects. Soluble IL-2R levels in the supernatants of cultured monocytes and AMs were higher in patients with sarcoidosis than in control subjects. Those of cultured T lymphocytes obtained from peripheral blood and bronchoalveolar lavage fluid were detected in some patients with sarcoidosis, while undetected in control subjects. Furthermore, soluble IL-2R in serum was significantly correlated with soluble IL-2R in the supernatants of cultured monocytes and AMs (p < 0.01 and p < 0.05, respectively). These results demonstrate that soluble IL-2R in serum is a useful index of the disease activity of sarcoidosis and is mainly derived from monocytes and AMs.
我们测定了结节病患者可溶性白细胞介素2受体（IL-2R）水平，并进一步研究了其来源。对39例结节病患者和18名健康对照者进行了研究。结节病患者血清中可溶性IL-2R水平显著高于对照组（p < 0.01）。在结节病中，活动期患者血清中可溶性IL-2R水平显著高于非活动期患者（p < 0.05），且与血清血管紧张素转换酶（ACE）水平显著相关（p < 0.01）。与对照组相比，结节病患者单核细胞和肺泡巨噬细胞（AMs）上的IL-2R表达显著增加（p < 0.01）。结节病患者培养的单核细胞和AMs上清液中的可溶性IL-2R水平高于对照组。部分结节病患者外周血和支气管肺泡灌洗液中培养的T淋巴细胞可检测到可溶性IL-2R，而对照组未检测到。此外，血清中的可溶性IL-2R与培养的单核细胞和AMs上清液中的可溶性IL-2R显著相关（分别为p < 0.01和p < 0.05）。这些结果表明，血清中的可溶性IL-2R是结节病疾病活动的一个有用指标，且主要来源于单核细胞和AMs。
