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关于N-甲基-N-β-氯乙基肼及其苯甲醛腙的胞质作用（作者译）

[On the cytosic action of N-methyl-N-beta-chloraethyl-hydrazine and its benzaldehydhydrazone (author's transl)].

作者信息

Braun R, Wolf G

出版信息

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Jun 15;86(2):127-33. doi: 10.1007/BF00284000.

DOI:10.1007/BF00284000
PMID:132785
Abstract

N-Methyl-N-beta-chloroethyl-hydrazine and its benzaldehydhydrazone are two new cytostatic methylhydrazines. Administered intraperitoneally, they are more effective in inhibiting the ascites tumor growth (Ehrlich's carcinoma in mice and Yoshida sarcoma in rats) than procarbazine in vitro as well as in vivo. The intraperitoneal administration of hydrazone shows a minor effect on the solid tumor. This may be explained by a different pharmacocinetical behaviour. Hydrazone is less toxic than procarbazine.

摘要

N-甲基-N-β-氯乙基肼及其苯甲醛腙是两种新型的具有抑制细胞生长作用的甲基肼。腹腔注射时，它们在体内外抑制腹水肿瘤生长（小鼠艾氏癌和大鼠吉田肉瘤）方面比丙卡巴肼更有效。腙的腹腔给药对实体瘤的作用较小。这可能是由于不同的药代动力学行为所致。腙的毒性比丙卡巴肼小。

相似文献

1
[On the cytosic action of N-methyl-N-beta-chloraethyl-hydrazine and its benzaldehydhydrazone (author's transl)].关于N-甲基-N-β-氯乙基肼及其苯甲醛腙的胞质作用（作者译）
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Jun 15;86(2):127-33. doi: 10.1007/BF00284000.
2
[On the cytostatic mechanism of action of N-methyl-N-beta-chloroethylhydrazine and its benzaldehydhydrazone (author's transl)].
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Dec 9;87(3):291-9. doi: 10.1007/BF00506502.
3
The influence of N-methyl-N-beta-chloroethyl hydrazines on the mitotic index of Ehrlich ascites tumor cells and the leukopoiesis of the mouse.
Experientia. 1977 Jan 15;33(1):66-7. doi: 10.1007/BF01936758.
4
On interactions of cytostatic benzylidine hydrazines with SH-groups.关于细胞抑制性亚苄基肼与巯基的相互作用
Chem Biol Interact. 1981 May;35(2):229-39. doi: 10.1016/0009-2797(81)90146-0.
5
Comparative investigation of the effect of ukrain on growth of ascites and solid forms of Ehrlich's carcinoma.乌克兰因对艾氏腹水癌和实体癌生长影响的比较研究
Exp Oncol. 2010 Jul;32(2):107-10.
6
[On structure-activity relationships of N'methyl-N'-beta-chloroethyl-benzaldehyde hydrazones (author's transl)].关于N-甲基-N-β-氯乙基苯甲醛腙的构效关系（作者译）
Arzneimittelforschung. 1977;27(11):2114-7.
7
[Effect of N'-methyl-N'-beta-chlorethylbenzaldehyde hydrazone on aerobic glycolysis in Ehrlich ascites cells].N'-甲基-N'-β-氯乙基苯甲醛腙对艾氏腹水癌细胞有氧糖酵解的影响
Arzneimittelforschung. 1978;28(1):13-6.
8
[Effect of N-methyl-N-beta-chloroethyl-hydrazine-HCl on the growth and multiplication of yeast cells (Saccharomyces cerevisiae) (author's transl)].盐酸N-甲基-N-β-氯乙基肼对酵母细胞（酿酒酵母）生长和繁殖的影响（作者译）
Z Naturforsch C Biosci. 1976 May-Jun;31(5-6):292-7.
9
[Investigation on radiosensitizing and tumor inhibiting actions of the antioxidant MTDQ (6,6'-methylen-bis/2,2,4-trimethyl-1-1,2-dihydroquinolin) (author's transl)].抗氧化剂MTDQ（6,6'-亚甲基双/2,2,4-三甲基-1,2-二氢喹啉）的放射增敏和抑瘤作用研究（作者译）
Arch Geschwulstforsch. 1975;45(5):489-95.
10
[Chemotherapy of murine Ehrlich carcinoma and rat Yoshida sarcoma transplanted on hamsters].[对移植于仓鼠的小鼠艾氏癌和大鼠吉田肉瘤的化学疗法]
Bratisl Lek Listy. 1970 Sep;54(3):262-74.

引用本文的文献

1
The influence of cytostatic methyl hydrazones on the intracellular pH and viability of tumor cells.细胞生长抑制剂甲基腙对肿瘤细胞内pH值和活力的影响。
Naturwissenschaften. 1980 Feb;67(2):103-4. doi: 10.1007/BF01054704.
2
[The immunosuppressive effects of N-methyl-N'-beta-chlorethylhydrazones].[N-甲基-N'-β-氯乙基腙的免疫抑制作用]
Naturwissenschaften. 1977 Jan;64(1):47-8. doi: 10.1007/BF00439905.
3
[Anti-leukemia effect of N'-methyl N'-beta-chlorethylhydrazones].[N'-甲基-N'-β-氯乙基腙的抗白血病作用]

本文引用的文献

1
[ON THE METABOLISM OF A CYTOSTATIC METHYLHYDRAZINE DERIVATIVE (NATULAN)].[关于一种细胞抑制剂甲基肼衍生物（丙卡巴肼）的代谢]
Experientia. 1965 Jan 15;21:44-5. doi: 10.1007/BF02136377.
2
[STUDIES ON THE CYTOSTATIC MECHANISM OF ACTION OF METHYLHYDRAZINE].
Hoppe Seylers Z Physiol Chem. 1964;336:271-82. doi: 10.1515/bchm2.1964.336.1.271.
3
THE TUMOR-INHIBITORY EFFECTS OF THE METHYLHYDRAZINE DERIVATIVE RO 4-6467/1 (NSC-77213).
Cancer Chemother Rep. 1963 Dec;33:1-4.
4
Naturwissenschaften. 1977 Jan;64(1):47. doi: 10.1007/BF00439904.
4
The influence of N-methyl-N-beta-chloroethyl hydrazines on the mitotic index of Ehrlich ascites tumor cells and the leukopoiesis of the mouse.
Experientia. 1977 Jan 15;33(1):66-7. doi: 10.1007/BF01936758.
5
[The anti-leukemic and immunosuppressive effect of methylhydrazones].[甲基腙的抗白血病及免疫抑制作用]
Naturwissenschaften. 1978 May;65(5):267-8. doi: 10.1007/BF00368582.
6
The influence of a new antitumor agent on hemopoietic colony forming cells.一种新型抗肿瘤药物对造血集落形成细胞的影响。
Experientia. 1978 Jun 15;34(6):765-7. doi: 10.1007/BF01947313.
7
Mutagenic activity of cytostatic methyl hydrazones with different strains of Salmonella typhimurium.
Arch Toxicol. 1979 Jul 11;42(3):179-84. doi: 10.1007/BF00353709.
Methylhydrazine derivatives, a new class of cytotoxic agents.
甲基肼衍生物，一类新型细胞毒性剂。
Experientia. 1963 Mar 15;19:129. doi: 10.1007/BF02171588.
5
Tumour inhibitory effects of a new class of cytotoxic agents: methylhydrazine derivatives.一类新型细胞毒性药物：甲基肼衍生物的肿瘤抑制作用。
Experientia. 1963 Mar 15;19:130-1. doi: 10.1007/BF02171589.
6
[N,N-dimethylhydrazinium salts as new growth regulators].
Naturwissenschaften. 1968 May;55(5):217-9. doi: 10.1007/BF00606204.
7
[Studies on the mechanism of cytostatic action of methylhydrazine, II].[甲基肼细胞生长抑制作用机制的研究，II]
Hoppe Seylers Z Physiol Chem. 1967 Apr;348(4):433-42.
8
Studies of the mode of action of N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide.N-异丙基-α-(2-甲基肼基)-对甲苯酰胺的作用模式研究。
Cancer Res. 1967 Jul;27(7):1186-91.
9
[beta-Chloro- and beta-mesylethyl hydrazines].[β-氯代和β-甲磺酰基乙肼]
Arch Pharm (Weinheim). 1974 Apr;307(4):272-7. doi: 10.1002/ardp.19743070406.