Gassel W D, Laukel H, Braun R, Wolf G
Experientia. 1978 Jun 15;34(6):765-7. doi: 10.1007/BF01947313.
The cytostatic and immunsuppressive agent N'-methyl-N'-beta-chloroethylbenzaldehyde hydrazone (B1) in in-vitro experiments has a stimulating effect on colony-forming culture (CFUc) of bone marrow from C57BL mice. This unusual behaviour, which is in contrast to other cytostatics, could also be observed in vitro with CFUc obtained from mice treated with therapeutic doses of B1 for 2 weeks. This stimulation is not a particular effect of B1 alone but seems to depend on a synergistic effect of the combination of B1 and the colony-stimulating activity (CSA) present in the serum from endotoxin-treated mice (MP) in the testing system. The results suggest that the described effect of B1 is due to an interference at the cell membrane of CFUc or their precursor cells.
细胞生长抑制剂和免疫抑制剂N'-甲基-N'-β-氯乙基苯甲醛腙（B1）在体外实验中对C57BL小鼠骨髓的集落形成培养（CFUc）有刺激作用。这种与其他细胞生长抑制剂相反的异常行为，在用治疗剂量的B1处理2周的小鼠所获得的CFUc的体外实验中也能观察到。这种刺激并非B1单独的特殊作用，而是似乎取决于测试系统中B1与内毒素处理小鼠（MP）血清中存在的集落刺激活性（CSA）相结合的协同效应。结果表明，B1的上述作用是由于对CFUc或其前体细胞的细胞膜产生干扰所致。
