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盐酸N-甲基-N-β-氯乙基肼对酵母细胞（酿酒酵母）生长和繁殖的影响（作者译）

[Effect of N-methyl-N-beta-chloroethyl-hydrazine-HCl on the growth and multiplication of yeast cells (Saccharomyces cerevisiae) (author's transl)].

作者信息

Braun R, Lange H

出版信息

Z Naturforsch C Biosci. 1976 May-Jun;31(5-6):292-7.

PMID:134572
Abstract

N-Methyl-N-beta-chloroethyl-hydrazine-HCl and its benzaldehydhydrazone inhibit growth and multiplication of yeast cells. The DNA-synthesis is partially blocked. After removal of the substances the rate of this synthesis is much more increased than that of RNA and protein. The both substances we tested are more effective than simple alkylhydrazines.

摘要

盐酸N-甲基-N-β-氯乙基肼及其苯甲醛腙可抑制酵母细胞的生长和繁殖。DNA合成被部分阻断。去除这些物质后，这种合成的速率比RNA和蛋白质的合成速率增加得更多。我们测试的这两种物质比简单的烷基肼更有效。

相似文献

1
[Effect of N-methyl-N-beta-chloroethyl-hydrazine-HCl on the growth and multiplication of yeast cells (Saccharomyces cerevisiae) (author's transl)].盐酸N-甲基-N-β-氯乙基肼对酵母细胞（酿酒酵母）生长和繁殖的影响（作者译）
Z Naturforsch C Biosci. 1976 May-Jun;31(5-6):292-7.
2
[Effect of N-methyl-N-beta-chloroethylhydrazine and its benzaldehydhydrazone on RNA-and protein synthesis as well as metabolism of synchronously growing yeast cells (Saccharomyces cerevisiae) (author's transl)].N-甲基-N-β-氯乙基肼及其苯甲醛腙对同步生长的酵母细胞（酿酒酵母）RNA和蛋白质合成以及代谢的影响（作者译）
Z Naturforsch C Biosci. 1976 May-Jun;31(5-6):298-303.
3
[On the cytostatic mechanism of action of N-methyl-N-beta-chloroethylhydrazine and its benzaldehydhydrazone (author's transl)].
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Dec 9;87(3):291-9. doi: 10.1007/BF00506502.
4
[Preparation of synchronously growing and multiplying yeast cells (Saccharomyces cerecisiae) (author's transl)].
Z Naturforsch C Biosci. 1975 Mar-Apr;30(2):245-7.
5
[On the cytosic action of N-methyl-N-beta-chloraethyl-hydrazine and its benzaldehydhydrazone (author's transl)].关于N-甲基-N-β-氯乙基肼及其苯甲醛腙的胞质作用（作者译）
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Jun 15;86(2):127-33. doi: 10.1007/BF00284000.
6
Rate of macromolecular synthesis through the cell cycle of the yeast Saccharomyces cerevisiae.酿酒酵母细胞周期中的大分子合成速率。
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4384-8. doi: 10.1073/pnas.75.9.4384.
7
Studies on the action of nalidixic acid in the yeast Saccharomyces cerevisiae.关于萘啶酸在酿酒酵母中的作用研究。
Antimicrob Agents Chemother. 1973 May;3(5):562-7. doi: 10.1128/AAC.3.5.562.
8
Inhibition by nalidixic acid of nucleic acid and protein synthesis in Saccharomyces cerevisiae [proceedings].
Biochem Soc Trans. 1977;5(5):1503-5. doi: 10.1042/bst0051503.
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Macromolecular synthesis during conjugation in yeast.酵母接合过程中的大分子合成。
Acta Microbiol Pol A. 1975;7(2):67-75.
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Mutagenesis of yeast by hydrazine: dependence upon post-treatment cell division.肼对酵母的诱变作用：依赖于处理后的细胞分裂
Mutat Res. 1977 May;43(2):165-77. doi: 10.1016/0027-5107(77)90002-1.

引用本文的文献

1
[Anti-leukemia effect of N'-methyl N'-beta-chlorethylhydrazones].[N'-甲基-N'-β-氯乙基腙的抗白血病作用]
Naturwissenschaften. 1977 Jan;64(1):47. doi: 10.1007/BF00439904.
2
The influence of N-methyl-N-beta-chloroethyl hydrazines on the mitotic index of Ehrlich ascites tumor cells and the leukopoiesis of the mouse.
Experientia. 1977 Jan 15;33(1):66-7. doi: 10.1007/BF01936758.
3
The influence of a new antitumor agent on hemopoietic colony forming cells.一种新型抗肿瘤药物对造血集落形成细胞的影响。
Experientia. 1978 Jun 15;34(6):765-7. doi: 10.1007/BF01947313.