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二乙基亚硝胺（DENA）对孔雀鱼（虹鳉）的毒理学效应（作者译）

[Toxicological effects of diethylinitrosamine (DENA) in guppies (Lebistes reticulatus) (author's transl)].

作者信息

Scherf H R

出版信息

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Jun 15;86(2):155-63. doi: 10.1007/BF00284003.

DOI:10.1007/BF00284003
PMID:132788
Abstract

In a chronical test guppies were incubated in the darkness in diethylnitrosamine-concentrations of 26 and 100 mg/1 up to seven months. This treatment led, because of the toxicity of the compound, to lesions in organs of the peritoneal cavity. Tumors were not observed. The cause of the lack of carcinogenic activity is discussed.

摘要

在一项长期试验中，将孔雀鱼置于黑暗环境中，使其接触浓度为26毫克/升和100毫克/升的二乙基亚硝胺，长达七个月。由于该化合物的毒性，这种处理导致腹腔器官出现病变。未观察到肿瘤。文中讨论了缺乏致癌活性的原因。

相似文献

1
[Toxicological effects of diethylinitrosamine (DENA) in guppies (Lebistes reticulatus) (author's transl)].二乙基亚硝胺（DENA）对孔雀鱼（虹鳉）的毒理学效应（作者译）
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Jun 15;86(2):155-63. doi: 10.1007/BF00284003.
2
Carcinogenesis of N-nitrosodiethylamine (DENA) in chickens and domestic cats.
Int J Cancer. 1978 Nov 15;22(5):552-7. doi: 10.1002/ijc.2910220508.
3
Carcinogenesis studies on guppies.孔雀鱼的致癌作用研究。
Natl Cancer Inst Monogr. 1984 May;65:71-81.
4
Foci of altered liver cells induced by a single dose of diethylnitrosamine and partial hepatectomy: their contribution to hepatocarcinogenesis in the rat.单次剂量二乙基亚硝胺及部分肝切除诱导的肝细胞改变灶：它们在大鼠肝癌发生中的作用。
Eur J Cancer (1965). 1975 Mar;11(3):145-54. doi: 10.1016/0014-2964(75)90109-7.
5
Hepatic lesions in Lebistes reticulatus induced by N-nitrosodiethylamine.
IARC Sci Publ. 1980(31):717-29.
6
Relative carcinogenic effectiveness of derivatives of nitrosodiethylamine in rats.
Cancer Res. 1978 Aug;38(8):2391-4.
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Carcinogenic effects of a single dose of diethylnitrosamine in three unrelated strains of mice: genetic dependence of the induced tumor types and incidence.单剂量二乙基亚硝胺对三种无关品系小鼠的致癌作用：诱导肿瘤类型和发生率的遗传依赖性
Cancer Lett. 1976 May;1(5):249-53. doi: 10.1016/s0304-3835(75)97372-3.
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Enhancement of diethylnitrosamine hepatocarcinogenesis in rats by exposure to polychlorinated biphenyls or phenobarbital.接触多氯联苯或苯巴比妥可增强二乙基亚硝胺诱导的大鼠肝癌发生。
Cancer Lett. 1976 Sep;2(1):11-5. doi: 10.1016/s0304-3835(76)80004-3.
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Carcinogenic dose-related response to nitrosamines.亚硝胺的致癌剂量相关反应。
Oncology. 1980;37(4):251-4. doi: 10.1159/000225446.
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Comparative studies of neoplastic response to a single dose of nitroso compounds. 6. The effect of diethylnitrosamine in Syrian golden hamsters.单剂量亚硝基化合物致癌反应的比较研究。6. 二乙基亚硝胺对叙利亚金仓鼠的影响。
J Cancer Res Clin Oncol. 1979 May 14;94(1):1-5. doi: 10.1007/BF00405344.

引用本文的文献

1
Genetics of susceptibility in the platyfish/swordtail tumor system to develop fibrosarcoma and rhabdomyosarcoma following treatment with N-methyl-N-nitrosourea (MNU).剑尾鱼/新月鱼肿瘤系统中经N-甲基-N-亚硝基脲（MNU）处理后发生纤维肉瘤和横纹肌肉瘤的易感性遗传学。
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1978;91(3):301-15. doi: 10.1007/BF00312292.

本文引用的文献

1
DIETHYLNITROSAMINE-INDUCED HEPATIC DEGENERATION AND NEOPLASIA IN THE AQUARIUM FISH, BRACHYDANIO RERIO.二乙基亚硝胺诱导斑马鱼肝脏变性和肿瘤形成
J Natl Cancer Inst. 1965 Jan;34:117-30. doi: 10.1093/jnci/34.1.117.
2
Carcinogenic action of dimethylnitrosamine in trout not related to methylation of nucleic acids and protein in vivo.二甲基亚硝胺在鳟鱼体内的致癌作用与核酸和蛋白质的体内甲基化无关。
Experientia. 1970 May 15;26(5):520-2. doi: 10.1007/BF01898485.
3
[Amylases, phosphorylase and related enzymes: nanogram demonstration in relation to polyacrylamide (PAA-)electrophoresis].
[淀粉酶、磷酸化酶及相关酶：与聚丙烯酰胺（PAA -）电泳相关的纳克级检测]
Naturwissenschaften. 1967 Mar;54(5):116-7.
4
Metabolism of dimethylnitrosamine by amphibians and fish in vitro.两栖动物和鱼类体外对二甲基亚硝胺的代谢
Experientia. 1973 May 15;29(5):599-601. doi: 10.1007/BF01926689.
5
Hepatic tumors in the guppy (Lebistes reticulatus) induced by aflatoxin B 1 , dimethylintrosamine, and 2-acetylaminofluorene.
J Natl Cancer Inst. 1973 Mar;50(3):767-78. doi: 10.1093/jnci/50.3.767.
6
[Induction of liver neoplasms by nitrosamines in aquarium fish Lebistes reticulatus (guppi)].亚硝胺对食蚊鱼（孔雀鱼）肝脏肿瘤的诱发作用
Vopr Onkol. 1971 Dec;17(12):67-72.
7
[Histogenesis and cytogenesis of cholangiocellular tumors in nitrosomorpholine-intoxicated rats. A contribution to the morphogenesis of polycystic disease of the liver].[亚硝基吗啉中毒大鼠胆管细胞肿瘤的组织发生和细胞发生。对肝多囊病形态发生的贡献]
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1971;76(3):193-215. doi: 10.1007/BF00303564.
8
Dimethylnitrosamine-induced hepatic cell carcinoma in rainbow trout.二甲基亚硝胺诱导虹鳟鱼肝细胞癌
J Natl Cancer Inst. 1968 Aug;41(2):531-52.
9
[Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].[65种不同N-亚硝基化合物对BD大鼠的器官特异性致癌作用]
Z Krebsforsch. 1967;69(2):103-201.
10
Dietary factors and hepatoma in rainbow trout (Salmo gairdneri). II. Cocarcinogenes by cyclopropenoid fatty acids and the effect of gossypol and altered lipids on aflatoxin-induced liver cancer.
J Natl Cancer Inst. 1968 Dec;41(6):1293-301.