Simon K, Lapis K
Natl Cancer Inst Monogr. 1984 May;65:71-81.
Guppies (Lebistes reticulatus) were used as models for the screening of potentially carcinogenic substances. These fish, a simple, readily accessible type, are sensitive toward carcinogens. Using this model, we performed studies on the morphological effects of a few water-soluble chemicals. Guppies treated with diethylnitrosamine were used as positive controls. Changes were noted in the livers, and a few specific lesions occurred in their gastrointestinal tracts. Studies were also conducted with 10 other similar chemicals found in the human environment that have potential use in chemotherapy. Of these, the carcinogenic effect of N,N'-dinitrosopiperazine on fish was demonstrated. Some researchers think this compound is a derivative of the pesticide Triforine. Furthermore, 2 of the 10 chemicals intended for use in therapy proved to be potential carcinogens. Because these experiments with water-soluble substances are inexpensive and the test periods are short, the use of fish is considered more advantageous than is the use of rodents.
孔雀鱼（虹鳉）被用作筛选潜在致癌物质的模型。这些鱼是一种简单、易于获取的类型，对致癌物敏感。利用这个模型，我们对几种水溶性化学物质的形态学效应进行了研究。用二乙基亚硝胺处理的孔雀鱼用作阳性对照。在肝脏中观察到了变化，并且在它们的胃肠道中出现了一些特定病变。还对在人类环境中发现的其他10种具有化疗潜在用途的类似化学物质进行了研究。其中，已证实N,N'-二硝基哌嗪对鱼类具有致癌作用。一些研究人员认为这种化合物是农药嗪氨灵的衍生物。此外，用于治疗的10种化学物质中有2种被证明是潜在致癌物。由于这些水溶性物质的实验成本低廉且测试周期短，因此使用鱼类被认为比使用啮齿动物更具优势。
