Popper H H, Wirnsberger G, Jüttner-Smolle F M, Pongratz M G, Sommersgutter M
Institute of Pathology, University of Graz, Austria.
Histopathology. 1992 Oct;21(4):323-30. doi: 10.1111/j.1365-2559.1992.tb00402.x.
Five solitary squamous papillomas of bronchus with variable degrees of dysplasia, one combined with a laryngeal papilloma and with a neuroendocrine carcinoma in the contralateral lung, and five papillomas combined with invasive squamous cell carcinomas were investigated for their expression of human papilloma virus DNA by in situ hybridization. Benign squamous cell papillomas showed an association with papilloma virus type 11 and rarely type 6, whereas types 16 or 18, sometimes in combination with types 31/33/35 were found in papillomas associated with carcinomas. In one patient a benign papilloma containing human papilloma virus type 18 and 31/33/35-positive preceded a recurrence combined with carcinoma by 2 years; this recurrent papilloma and the carcinoma were also positive for human papilloma virus 18 DNA. We suggest that human papilloma virus typing should be performed in every squamous cell papilloma of bronchus. Patients with papillomas exhibiting human papilloma virus 16 or 18 positivity are at high risk for the development of squamous cell carcinoma. Furthermore, virus typing may be of prognostic importance in relation to the development of squamous carcinoma.
对5例伴有不同程度发育异常的支气管孤立性鳞状乳头状瘤、1例合并喉乳头状瘤且对侧肺有神经内分泌癌的病例以及5例合并浸润性鳞状细胞癌的乳头状瘤进行原位杂交，检测人乳头瘤病毒DNA的表达。良性鳞状细胞乳头状瘤与11型乳头瘤病毒相关，很少与6型相关，而在与癌相关的乳头状瘤中发现16或18型，有时与31/33/35型联合存在。1例患者的良性乳头状瘤含有18型人乳头瘤病毒且31/33/35型阳性，2年后复发并合并癌；该复发性乳头状瘤和癌的人乳头瘤病毒18 DNA也呈阳性。我们建议对每例支气管鳞状细胞乳头状瘤都应进行人乳头瘤病毒分型。显示人乳头瘤病毒16或18阳性的乳头状瘤患者发生鳞状细胞癌的风险很高。此外，病毒分型对于鳞状细胞癌的发生可能具有预后意义。
