Rogeness G A, Javors M A, Pliszka S R
Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284-7792.
J Am Acad Child Adolesc Psychiatry. 1992 Sep;31(5):765-81. doi: 10.1097/00004583-199209000-00001.
This article reviews some of the neurochemistry and neurophysiology of three neurotransmitters: dopamine, norepinephrine, and serotonin. These neurotransmitters are selected because they appear to be involved in the regulation of several important behavioral systems that help regulate the interaction of the organism with its external environment, because many of the psychotropic drugs' modes of action may be result from their effects on these neurotransmitter systems, and because the majority of neurochemical studies in child psychiatry have focused on these three neurotransmitters. After the review of the neurotransmitter systems, neurochemical studies in several child psychiatric disorders are reviewed to illustrate possible biochemical/behavioral relationships in child psychiatry.
本文综述了三种神经递质——多巴胺、去甲肾上腺素和血清素的一些神经化学和神经生理学知识。选择这些神经递质是因为它们似乎参与了几个重要行为系统的调节，这些系统有助于调节生物体与其外部环境的相互作用；还因为许多精神药物的作用模式可能源于它们对这些神经递质系统的影响；另外也是因为儿童精神病学中的大多数神经化学研究都集中在这三种神经递质上。在对神经递质系统进行综述之后，本文还将对几种儿童精神疾病的神经化学研究进行综述，以阐明儿童精神病学中可能存在的生化/行为关系。
