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利用细针穿刺对小圆细胞肿瘤进行细胞遗传学特征分析。

Cytogenetic characterisation of small round cell tumours using fine needle aspiration.

作者信息

Sreekantaiah C, Appaji L, Hazarika D

机构信息

Kidwai Memorial Institute of Oncology, Bangalore, India.

出版信息

J Clin Pathol. 1992 Aug;45(8):728-30. doi: 10.1136/jcp.45.8.728.

DOI:10.1136/jcp.45.8.728
PMID:1328328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC495157/
Abstract

Cytogenetic analysis of short term cultures of fine needle aspirates from two tumours, characterised cytologically as small round cell neoplasms, showed specific clonal chromosomal abnormalities. In both cases the cytogenetic finding of a t(11; 22) (q24; q12) helped determine their diagnosis as peripheral neuroectodermal tumours of the thoraco-pulmonary region (Askin's tumour). These findings suggest that cytogenetics can reliably distinguish neoplasms which present as undifferentiated small round cell tumours.

摘要

对两个肿瘤的细针穿刺短期培养物进行细胞遗传学分析，这两个肿瘤在细胞学上被表征为小圆形细胞瘤，结果显示出特定的克隆性染色体异常。在这两个病例中，细胞遗传学发现的t(11; 22) (q24; q12)有助于将它们诊断为胸肺区域的外周神经外胚层肿瘤（阿斯金瘤）。这些发现表明，细胞遗传学能够可靠地区分表现为未分化小圆形细胞肿瘤的肿瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e0/495157/49d30b5965d6/jclinpath00422-0087-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e0/495157/2f9048cfe8bb/jclinpath00422-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e0/495157/49d30b5965d6/jclinpath00422-0087-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e0/495157/2f9048cfe8bb/jclinpath00422-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e0/495157/49d30b5965d6/jclinpath00422-0087-b.jpg

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本文引用的文献

1
Fine needle aspiration biopsy: a useful tool in tumor cytogenetics with special reference to malignant lymphomas.细针穿刺活检：肿瘤细胞遗传学中的一种有用工具，特别涉及恶性淋巴瘤。
Cancer Genet Cytogenet. 1981 Aug;4(1):53-60. doi: 10.1016/0165-4608(81)90008-x.
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The usefulness of percutaneous fine-needle aspiration biopsy in infants and children.经皮细针穿刺活检在婴幼儿及儿童中的应用价值。
J Pediatr Surg. 1983 Aug;18(4):398-405. doi: 10.1016/s0022-3468(83)80189-4.
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Small cell tumours in childhood: a review.儿童期小细胞肿瘤：综述
J Pathol. 1985 Jan;145(1):1-25. doi: 10.1002/path.1711450102.
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Chromosomes in Ewing's sarcoma. I. An evaluation of 85 cases of remarkable consistency of t(11;22)(q24;q12).
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Cytogenetic characterization of selected small round cell tumors of childhood.儿童特定小圆细胞肿瘤的细胞遗传学特征
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Fine-needle aspiration biopsy diagnosis of round cell malignant tumors of childhood. A combined light and electron microscopic approach.儿童圆形细胞恶性肿瘤的细针穿刺活检诊断。光镜与电镜联合检查方法。
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t(11;22) in three cases of peripheral neuroepithelioma.3例周围神经上皮瘤中存在t(11;22)。
Genes Chromosomes Cancer. 1990 Jul;2(2):163-5. doi: 10.1002/gcc.2870020213.
8
Genetic analysis as an aid in diagnosis for patients with midline carcinomas of uncertain histologies.基因分析辅助诊断组织学类型不明的中线癌患者。
J Natl Cancer Inst. 1991 Mar 6;83(5):341-6. doi: 10.1093/jnci/83.5.341.