Ormerod L D, Garsd A, Abelson M B, Kenyon K R
Eye Research Institute, Boston, Massachusetts.
J Ocul Pharmacol. 1992 Spring;8(1):53-8. doi: 10.1089/jop.1992.8.53.
The cyclooxygenase and lipoxygenase enzyme systems can metabolize a number of C20 polyunsaturated fatty acids. Although arachidonic acid is the usual substrate for these pathways, the eicosanoid precursor pool can be nutritionally manipulated by supplementation with alternative precursors, often generating less active or down-regulatory metabolic products. Prefeeding with gamma-linolenic acid, eicosapentaenoic acid, or a combination of both failed to influence the lagphase, epithelial migration rate, or epithelial wound healing kinetics after either 1N or 4N NaOH alkali burning of the rabbit cornea. Initial epithelial wound healing probably does not involve eicosanoid-mediated processes. Essentially linear epithelial healing kinetics continued to closure without a late decrease in wound edge velocity.
环氧化酶和脂氧化酶系统可代谢多种C20多不饱和脂肪酸。尽管花生四烯酸是这些途径的常见底物，但类二十烷酸前体库可通过补充替代前体进行营养调控，这些替代前体通常会产生活性较低或具有下调作用的代谢产物。用γ-亚麻酸、二十碳五烯酸或两者的组合进行预喂养，对兔角膜进行1N或4N氢氧化钠碱烧伤后，均未影响延迟期、上皮迁移率或上皮伤口愈合动力学。初始上皮伤口愈合可能不涉及类二十烷酸介导的过程。上皮愈合动力学基本呈线性，持续至伤口闭合，伤口边缘速度无后期下降情况。
