Hemmati-Brivanlou A, Melton D A
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.
Nature. 1992 Oct 15;359(6396):609-14. doi: 10.1038/359609a0.
Activins can induce mesoderm in embryonic explants and have been proposed as the natural inducer in Xenopus. A mutant activin receptor that inhibits activin signalling is used to show that activin is required for the induction of mesoderm in vivo and the patterning of the embryonic body plan. Blocking the activin signal transduction pathway also reveals autonomous induction of a neural marker and unmasks a relationship between activin and fibroblast growth factor.
激活素可在胚胎外植体中诱导中胚层形成，并且已被认为是非洲爪蟾中的天然诱导因子。一种抑制激活素信号传导的突变型激活素受体被用于证明激活素在体内中胚层诱导及胚胎体轴模式形成中是必需的。阻断激活素信号转导途径还揭示了神经标志物的自主诱导，并揭示了激活素与成纤维细胞生长因子之间的关系。
