Freire-Garabal M, Belmonte A, Balboa J L, Núñez M J
Department of Pharmacology, Faculty of Medicine, University of Santiago de Compostela, Spain.
Pharmacol Biochem Behav. 1992 Sep;43(1):85-9. doi: 10.1016/0091-3057(92)90642-s.
Mice submitted to surgical stress induced by laparotomy and treated with chronic midazolam (1 mg/kg) showed a reduction in stress-induced suppression of thymus and spleen cellularity and in peripheral lymphocyte population. The blastogenic response of spleen lymphoid cells was also assessed and midazolam was found to partially attenuate the suppressive effect of surgery.
接受剖腹手术诱导的手术应激并接受慢性咪达唑仑（1毫克/千克）治疗的小鼠，其应激诱导的胸腺和脾脏细胞数量抑制以及外周淋巴细胞数量均有所减少。还评估了脾脏淋巴样细胞的增殖反应，发现咪达唑仑可部分减轻手术的抑制作用。
